Scientific article
Review
English

Germline CBM-opathies: From immunodeficiency to atopy

Published inJournal of Allergy and Clinical Immunology, vol. 143, no. 5, p. 1661-1673
Publication date2019
Abstract

Caspase recruitment domain (CARD) protein-B cell CLL/lymphoma 10 (BCL10)-MALT1 paracaspase (MALT1) [CBM] complexes are critical signaling adaptors that facilitate immune and inflammatory responses downstream of both cell surface and intracellular receptors. Germline mutations that alter the function of members of this complex (termed CBM-opathies) cause a broad array of clinical phenotypes, ranging from profound combined immunodeficiency to B-cell lymphocytosis. With an increasing number of patients being described in recent years, the clinical spectrum of diseases associated with CBM-opathies is rapidly expanding and becoming unexpectedly heterogeneous. Here we review major discoveries that have shaped our understanding of CBM complex biology, and we provide an overview of the clinical presentation, diagnostic approach, and treatment options for those carrying germline mutations affecting CARD9, CARD11, CARD14, BCL10, and MALT1.

Keywords
  • BCL10
  • CARD11
  • CARD14
  • CARD9
  • CBM-opathies
  • MALT1
  • Combined immunodeficiency
  • Congenital B-cell lymphocytosis
  • Primary atopic disease
  • Primary immunodeficiencies
Citation (ISO format)
LU, Henry Y et al. Germline CBM-opathies: From immunodeficiency to atopy. In: Journal of Allergy and Clinical Immunology, 2019, vol. 143, n° 5, p. 1661–1673. doi: 10.1016/j.jaci.2019.03.009
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Journal ISSN0091-6749
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