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Title

Foreign body infections due to Staphylococcus epidermidis

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Published in Annals of Medicine. 2009, vol. 41, no. 2, p. 109-19
Abstract Staphylococcal infections are one of the main causes of complications in patients with implanted foreign prosthetic material. Implants are associated with a significant reduction of the threshold at which contaminating Gram-positive bacteria, particularly Staphylococcus epidermidis, become infectious and develop a biofilm with phenotypic resistance to almost all antibiotics. A 1000-fold increase in minimal bactericidal levels against most antibiotics except rifampin has been repeatedly observed. Since only removal of the foreign material reverses these phenomena, the clinical challenge consists in finding approaches to cure the infection without removal of the implanted device. Rifampin combinations with other antibiotics, administration of exceedingly high antibiotic concentrations in situ, and early therapy before biofilm development are efficacious. Although these strategies have dramatically improved the outcome of foreign body infections, an improved understanding of biofilm-grown S. epidermidis is necessary to develop new antibacterial agents. Here, we review the pathogenesis, prevention, and treatment of implant infections due to S. epidermidis and highlight some new compounds with already promising in vitro results.
Keywords Anti-Bacterial Agents/administration & dosageAntibiotic ProphylaxisBiofilms/growth & developmentCatheterization, Central Venous/adverse effectsCatheters, Indwelling/microbiologyDrug Resistance, BacterialDrug Therapy, CombinationForeign Bodies/microbiologyHumansJoint Prosthesis/adverse effects/microbiologyProsthesis FailureProsthesis-Related Infections/drug therapy/microbiology/prevention & controlStaphylococcal Infections/drug therapy/prevention & controlStaphylococcus epidermidis/drug effects/physiology
Stable URL https://archive-ouverte.unige.ch/unige:1450
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Identifiers
PMID: 18720093
Structures
Research groups Glycopeptide résistance (28)
Staphylocoques dorés résistants à la méthicilline et hygiène hospitalière (330)

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Deposited on : 2009-04-29

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