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Title

How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept

Authors
Som, Claudia
Schmutz, Mélanie
Borges, Olga
Published in Frontiers in bioengineering and biotechnology. 2020, vol. 8
Abstract Efficacy and safety of nanomedicines based on polymeric (bio)materials will benefit from a rational implementation of a Safe-by-Design (SbD) approach throughout their development. In order to achieve this goal, however, a standardization of preparation and characterization methods and their accurate reporting is needed. Focusing on the example of chitosan, a biopolymer derived from chitin and frequently used in drug and vaccine delivery vector preparation, this review discusses the challenges still to be met and overcome prior to a successful implementation of the SbD approach to the preparation of chitosan-based protein drug delivery systems
Keywords Safe by designPolymeric drug carriersChitosanInsulinProtein drug delivery
Identifiers
PMID: 32211394
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Research group Biopharmacie
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MARQUES, Cintia et al. How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept. In: Frontiers in Bioengineering and Biotechnology, 2020, vol. 8. doi: 10.3389/fbioe.2020.00165 https://archive-ouverte.unige.ch/unige:144873

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Deposited on : 2020-11-18

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