en
Scientific article
Review
Open access
English

How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept

Publication date2020
Abstract

Efficacy and safety of nanomedicines based on polymeric (bio)materials will benefit from a rational implementation of a Safe-by-Design (SbD) approach throughout their development. In order to achieve this goal, however, a standardization of preparation and characterization methods and their accurate reporting is needed. Focusing on the example of chitosan, a biopolymer derived from chitin and frequently used in drug and vaccine delivery vector preparation, this review discusses the challenges still to be met and overcome prior to a successful implementation of the SbD approach to the preparation of chitosan-based protein drug delivery systems

Keywords
  • Safe by design
  • Polymeric drug carriers
  • Chitosan
  • Insulin
  • Protein drug delivery
Research group
Citation (ISO format)
MARQUES, Cintia et al. How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept. In: Frontiers in Bioengineering and Biotechnology, 2020, vol. 8. doi: 10.3389/fbioe.2020.00165
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal2296-4185
165views
69downloads

Technical informations

Creation11/10/2020 10:56:00 AM
First validation11/10/2020 10:56:00 AM
Update time03/15/2023 11:22:59 PM
Status update03/15/2023 11:22:59 PM
Last indexation10/19/2023 2:02:34 PM
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