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Title

How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept
Authors
Marques, Cintia
Som, Claudia
Schmutz, Mélanie
Borges, Olga
Borchard, Gerrit
Published in Frontiers in bioengineering and biotechnology. 2020, vol. 8
Abstract Efficacy and safety of nanomedicines based on polymeric (bio)materials will benefit from a rational implementation of a Safe-by-Design (SbD) approach throughout their development. In order to achieve this goal, however, a standardization of preparation and characterization methods and their accurate reporting is needed. Focusing on the example of chitosan, a biopolymer derived from chitin and frequently used in drug and vaccine delivery vector preparation, this review discusses the challenges still to be met and overcome prior to a successful implementation of the SbD approach to the preparation of chitosan-based protein drug delivery systems
Keywords Safe by design — Polymeric drug carriers — Chitosan — Insulin — Protein drug delivery
Identifiers
PMID: 32211394
Full text
Article (Published version) (697 Kb) - public document Free access
Other version: https://www.frontiersin.org/article/10.3389/fbioe.2020.00165/full
Structures
Faculté des sciences / Section des sciences pharmaceutiques
Research group Biopharmacie
Citation
(ISO format) 		MARQUES, Cintia et al. How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept. In: Frontiers in Bioengineering and Biotechnology, 2020, vol. 8. doi: 10.3389/fbioe.2020.00165 https://archive-ouverte.unige.ch/unige:144873

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Deposited on : 2020-11-18

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