

Other version: https://clincancerres.aacrjournals.org/content/25/8/2483.full-text.pdf
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Epigenetic Silencing Affects l-Asparaginase Sensitivity and Predicts Outcome in T-ALL |
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Published in | Clinical Cancer Research. 2019, vol. 25, no. 8, p. 2483-2493 | |
Abstract | Biological explanation for discrepancies in patient-related response to chemotherapy depending on the underlying oncogenic events is a promising research area. TLX1- or TLX3-deregulated T-cell acute lymphoblastic leukemias (T-ALL; TLX1/3+) share an immature cortical phenotype and similar transcriptional signatures. However, their prognostic impacts differ, and inconsistent clinical outcome has been reported for TLX3. We therefore hypothesized that the overlapping transcriptional profiles of TLX1+ and TLX3+ T-ALLs would allow identification of candidate genes, which might determine their distinct clinical outcomes. | |
Keywords | Adolescent — Adult — Age Factors — Antineoplastic Agents/administration & dosage/adverse effects/pharmacology — Asparaginase/administration & dosage/adverse effects/pharmacology — Cell Line, Tumor — DNA Methylation — Drug Resistance, Neoplasm/genetics — Epigenesis, Genetic — Female — Gene Expression Profiling — Gene Expression Regulation, Neoplastic — Gene Silencing — Humans — Kaplan-Meier Estimate — Male — Middle Aged — Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/genetics/mortality/pathology — Prognosis — Promoter Regions, Genetic — Transcriptome — Young Adult | |
Identifiers | PMID: 30659025 | |
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![]() ![]() Other version: https://clincancerres.aacrjournals.org/content/25/8/2483.full-text.pdf |
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Structures | ||
Research group | Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982) | |
Citation (ISO format) | TOUZART, Aurore et al. Epigenetic Silencing Affects l-Asparaginase Sensitivity and Predicts Outcome in T-ALL. In: Clinical Cancer Research, 2019, vol. 25, n° 8, p. 2483-2493. doi: 10.1158/1078-0432.CCR-18-1844 https://archive-ouverte.unige.ch/unige:144872 |