Epigenetic Silencing Affects l-Asparaginase Sensitivity and Predicts Outcome in T-ALL

Touzart, Aurore; Lengliné, Etienne; Latiri, Mehdi; Belhocine, Mohamed; Smith, Charlotte; Thomas, Xavier; Spicuglia, Salvatore; Puthier, Denis; Pflumio, Françoise; Leguay, Thibaut; Graux, Carlos; Chalandon, Yves; Huguet, Françoise; Leprêtre, Stéphane; Ifrah, Norbert; Dombret, Hervé; Macintyre, Elizabeth; Hunault, Mathilde; Boissel, Nicolas; Asnafi, Vahid

doi:10.1158/1078-0432.CCR-18-1844

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Title		Epigenetic Silencing Affects l-Asparaginase Sensitivity and Predicts Outcome in T-ALL
Authors		Touzart, Aurore Lengliné, Etienne Latiri, Mehdi Belhocine, Mohamed Smith, Charlotte Thomas, Xavier Spicuglia, Salvatore Puthier, Denis Pflumio, Françoise Leguay, Thibaut Graux, Carlos Chalandon, Yves Huguet, Françoise Leprêtre, Stéphane Ifrah, Norbert Dombret, Hervé Macintyre, Elizabeth Hunault, Mathilde Boissel, Nicolas Asnafi, Vahid show all authors [1 - 20]
Published in		Clinical Cancer Research. 2019, vol. 25, no. 8, p. 2483-2493
Abstract		Biological explanation for discrepancies in patient-related response to chemotherapy depending on the underlying oncogenic events is a promising research area. TLX1- or TLX3-deregulated T-cell acute lymphoblastic leukemias (T-ALL; TLX1/3+) share an immature cortical phenotype and similar transcriptional signatures. However, their prognostic impacts differ, and inconsistent clinical outcome has been reported for TLX3. We therefore hypothesized that the overlapping transcriptional profiles of TLX1+ and TLX3+ T-ALLs would allow identification of candidate genes, which might determine their distinct clinical outcomes.
Keywords		Adolescent — Adult — Age Factors — Antineoplastic Agents/administration & dosage/adverse effects/pharmacology — Asparaginase/administration & dosage/adverse effects/pharmacology — Cell Line, Tumor — DNA Methylation — Drug Resistance, Neoplasm/genetics — Epigenesis, Genetic — Female — Gene Expression Profiling — Gene Expression Regulation, Neoplastic — Gene Silencing — Humans — Kaplan-Meier Estimate — Male — Middle Aged — Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/genetics/mortality/pathology — Prognosis — Promoter Regions, Genetic — Transcriptome — Young Adult
Identifiers		DOI: 10.1158/1078-0432.CCR-18-1844 PMID: 30659025
Full text		Article (Published version) (1.1 MB) - Limited access to UNIGE Other version: https://clincancerres.aacrjournals.org/content/25/8/2483.full-text.pdf
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Research group		Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)
Citation (ISO format)		TOUZART, Aurore et al. Epigenetic Silencing Affects l-Asparaginase Sensitivity and Predicts Outcome in T-ALL. In: Clinical Cancer Research, 2019, vol. 25, n° 8, p. 2483-2493. doi: 10.1158/1078-0432.CCR-18-1844 https://archive-ouverte.unige.ch/unige:144872