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Epigenetic Silencing Affects l-Asparaginase Sensitivity and Predicts Outcome in T-ALL

Touzart, Aurore
Lengliné, Etienne
Latiri, Mehdi
Belhocine, Mohamed
Smith, Charlotte
Thomas, Xavier
Spicuglia, Salvatore
Puthier, Denis
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Published in Clinical Cancer Research. 2019, vol. 25, no. 8, p. 2483-2493
Abstract Biological explanation for discrepancies in patient-related response to chemotherapy depending on the underlying oncogenic events is a promising research area. TLX1- or TLX3-deregulated T-cell acute lymphoblastic leukemias (T-ALL; TLX1/3+) share an immature cortical phenotype and similar transcriptional signatures. However, their prognostic impacts differ, and inconsistent clinical outcome has been reported for TLX3. We therefore hypothesized that the overlapping transcriptional profiles of TLX1+ and TLX3+ T-ALLs would allow identification of candidate genes, which might determine their distinct clinical outcomes.
Keywords AdolescentAdultAge FactorsAntineoplastic Agents/administration & dosage/adverse effects/pharmacologyAsparaginase/administration & dosage/adverse effects/pharmacologyCell Line, TumorDNA MethylationDrug Resistance, Neoplasm/geneticsEpigenesis, GeneticFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGene SilencingHumansKaplan-Meier EstimateMaleMiddle AgedPrecursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/genetics/mortality/pathologyPrognosisPromoter Regions, GeneticTranscriptomeYoung Adult
PMID: 30659025
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Research group Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)
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TOUZART, Aurore et al. Epigenetic Silencing Affects l-Asparaginase Sensitivity and Predicts Outcome in T-ALL. In: Clinical Cancer Research, 2019, vol. 25, n° 8, p. 2483-2493. doi: 10.1158/1078-0432.CCR-18-1844 https://archive-ouverte.unige.ch/unige:144872

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Deposited on : 2020-11-18

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