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Title

Successful Treatment of Saksenaea sp. Osteomyelitis by Conservative Surgery and Intradiaphyseal Incorporation of Amphotericin B Cement Beads

Authors
Parize, Perrine
Garcia-Hermoso, Dea
Dumaine, Valérie
Poirée, Sylvain
Kauffmann-Lacroix, Catherine
Lortholary, Olivier
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Published in Antimicrobial Agents and Chemotherapy. 2019, vol. 63, no. 1, p. e01006-18
Abstract Osteoarticular mucormycosis cases are quite rare and challenging infections that are mostly due to direct inoculation during traumatic injury among immunocompetent patients. Classic management includes a combination of aggressive surgical debridement, which may lead to amputation, and long-term systemic liposomal amphotericin B therapy. This article describes the successful treatment of Saksenaea sp. osteomyelitis in a patient with diabetes mellitus, using a combination of systemic antifungal therapy and conservative surgery with insertion of amphotericin-impregnated cement beads.
Keywords Amphotericin B/administration & dosage/therapeutic useAntifungal Agents/therapeutic useDebridementDiabetes Complications/microbiologyDiabetes MellitusDrug Carriers/therapeutic useHumansMaleMiddle AgedMucorales/drug effectsMucormycosis/drug therapy/microbiologyOsteomyelitis/drug therapy/microbiology/surgery
Identifiers
PMID: 30373790
Full text
Research group Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)
Citation
(ISO format)
PARIZE, Perrine et al. Successful Treatment of Saksenaea sp. Osteomyelitis by Conservative Surgery and Intradiaphyseal Incorporation of Amphotericin B Cement Beads. In: Antimicrobial Agents and Chemotherapy, 2019, vol. 63, n° 1, p. e01006-18. doi: 10.1128/AAC.01006-18 https://archive-ouverte.unige.ch/unige:144856

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Deposited on : 2020-11-18

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