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T cell immunity. Functional heterogeneity of human memory CD4⁺ T cell clones primed by pathogens or vaccines

Latorre, Daniela
Mele, Federico
Foglierini, Mathilde
De Gregorio, Corinne
Cassotta, Antonino
Fernandez, Blanca
Kelderman, Sander
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Published in Science. 2015, vol. 347, no. 6220, p. 400-406
Abstract Distinct types of CD4(+) T cells protect the host against different classes of pathogens. However, it is unclear whether a given pathogen induces a single type of polarized T cell. By combining antigenic stimulation and T cell receptor deep sequencing, we found that human pathogen- and vaccine-specific T helper 1 (T(H)1), T(H)2, and T(H)17 memory cells have different frequencies but comparable diversity and comprise not only clones polarized toward a single fate, but also clones whose progeny have acquired multiple fates. Single naïve T cells primed by a pathogen in vitro could also give rise to multiple fates. Our results unravel an unexpected degree of interclonal and intraclonal functional heterogeneity of the human T cell response and suggest that polarized responses result from preferential expansion rather than priming.
Keywords Amino Acid SequenceCD4-Positive T-Lymphocytes/immunologyCandida albicans/immunologyCellsCulturedClone CellsHigh-Throughput Nucleotide SequencingHost-Pathogen Interactions/immunologyHumansImmunologic MemoryLymphocyte ActivationMolecular Sequence DataMycobacterium tuberculosis/immunologyReceptorsAntigenT-Cell/geneticsT-Lymphocyte Subsets/immunologyTh1 Cells/immunologyTh17 Cells/immunologyTh2 Cells/immunologyVaccines/immunology
PMID: 25477212
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Research group Groupe Simone Becattini (1027)
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BECATTINI, Simone et al. T cell immunity. Functional heterogeneity of human memory CD4⁺ T cell clones primed by pathogens or vaccines. In: Science, 2015, vol. 347, n° 6220, p. 400-406. doi: 10.1126/science.1260668

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Deposited on : 2020-11-18

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