Detection of Anti-Cardiolipin and Anti-β2glycoprotein I Antibodies Differs between Platforms without Influence on Association with Clinical Symptoms

Chayoua, Walid; Kelchtermans, Hilde; Moore, Gary; Gris, Jean-Christophe; Musial, Jacek; Wahl, Denis; Zuily, Stéphane; Gianniello, Francesca; Fontana, Pierre; Remijn, Jasper; Urbanus, Rolf; de Laat, Bas; Devreese, Katrien

doi:10.1055/s-0039-1679901

Scientific article

English

Detection of Anti-Cardiolipin and Anti-β2glycoprotein I Antibodies Differs between Platforms without Influence on Association with Clinical Symptoms

ContributorsChayoua, Walid; Kelchtermans, Hilde; Moore, Gary; Gris, Jean-Christophe; Musial, Jacek; Wahl, Denis; Zuily, Stéphane; Gianniello, Francesca; Fontana, Pierre; Remijn, Jasper; Urbanus, Rolf; de Laat, Bas; Devreese, Katrien

Published inThrombosis and Haemostasis, vol. 119, no. 05, p. 797-806

Publication date2019

Abstract

Background: The anti-phospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity with persistent presence of anti-phospholipid antibodies (aPL). Laboratory criteria include aPL detection by coagulation tests for lupus anticoagulant (LAC) or solid phase assays measuring anti-β2 glycoprotein I (aβ2GPI) or anti-cardiolipin (aCL) immunoglobulin (Ig) G/IgM antibodies. External quality control programs illustrate that commercially available aPL assays produce variable results. Objective: We aimed to investigate the agreement and diagnostic accuracy of solid phase assays.

Keywords

Solid phase assays
Anti-cardiolipin
β2 glycoprotein I
Epitope
Thrombosis

Affiliation

Faculté de médecine / Section de médecine clinique / Département de médecine

Research group

Geneva Platelet Group (13)

Citation (ISO format)

CHAYOUA, Walid et al. Detection of Anti-Cardiolipin and Anti-β2glycoprotein I Antibodies Differs between Platforms without Influence on Association with Clinical Symptoms. In: Thrombosis and Haemostasis, 2019, vol. 119, n° 05, p. 797–806. doi: 10.1055/s-0039-1679901

Article (Published version)

Identifiers

PID : unige:144739
DOI : 10.1055/s-0039-1679901
PMID : 30822809

Commercial URLhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0039-1679901.pdf

ISSN of the journal0340-6245

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Detection of Anti-Cardiolipin and Anti-β2glycoprotein I Antibodies Differs between Platforms without Influence on Association with Clinical Symptoms

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