Reversible Sensing of the Anticoagulant Heparin with Protamine Permselective Membranes

Crespo Paravano, Gaston Adrian; Afshar, Majid Ghahraman; Bakker, Eric

doi:10.1002/anie.201207444

Scientific article

English

Reversible Sensing of the Anticoagulant Heparin with Protamine Permselective Membranes

ContributorsCrespo Paravano, Gaston Adrian; Afshar, Majid Ghahraman; Bakker, Eric

Published inAngewandte Chemie: International Edition, vol. 51, no. 50, p. 12575-12578

Publication date2012

Abstract

A permselective membrane electrode allows the rapid and operationally reversible detection of the polycationic polypeptide protamine in physiological samples. Anticoagulant levels of heparin can be measured in undiluted whole blood by adding a known excess of its antidote protamine to discrete blood samples.

Keywords

Blood
Flash chronopotentiometry
Heparin
Permselective membranes
Protamine

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie minérale, analytique et appliquée

Citation (ISO format)

CRESPO PARAVANO, Gaston Adrian, AFSHAR, Majid Ghahraman, BAKKER, Eric. Reversible Sensing of the Anticoagulant Heparin with Protamine Permselective Membranes. In: Angewandte Chemie: International Edition, 2012, vol. 51, n° 50, p. 12575–12578. doi: 10.1002/anie.201207444

Article (Published version)

Identifiers

PID : unige:144407
DOI : 10.1002/anie.201207444

Additional URL for this publicationhttp://doi.wiley.com/10.1002/anie.201207444

Journal ISSN1433-7851

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Reversible Sensing of the Anticoagulant Heparin with Protamine Permselective Membranes

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