Scientific article
English

An antimicrobial bicyclic peptide from chemical space against multidrug resistant Gram-negative bacteria

Published inChemical Communications, vol. 54, no. 40, p. 5130-5133
Publication date2018
Abstract

We used the concept of chemical space to explore a virtual library of bicyclic peptides formed by double thioether cyclization of a precursor linear peptide, and identified an antimicrobial bicyclic peptide (AMBP) with remarkable activity against several MDR strains of Acinetobacter baumannii and Pseudomonas aeruginosa.

Keywords
  • Acinetobacter baumannii/drug effects
  • Anti-Bacterial Agents/chemistry/pharmacology
  • Antimicrobial Cationic Peptides/chemistry/pharmacology
  • Bacillus subtilis/drug effects
  • Biofilms/drug effects
  • Cell Membrane/drug effects
  • Drug Evaluation
  • Preclinical/methods
  • Drug Resistance
  • Multiple
  • Bacterial/drug effects
  • Humans
  • Microbial Sensitivity Tests
  • Molecular Dynamics Simulation
  • Peptides
  • Cyclic/chemistry/pharmacology
  • Protein Structure
  • Secondary
  • Pseudomonas aeruginosa/drug effects
  • Small Molecule Libraries/chemistry/pharmacology
Citation (ISO format)
DI BONAVENTURA, Ivan et al. An antimicrobial bicyclic peptide from chemical space against multidrug resistant Gram-negative bacteria. In: Chemical Communications, 2018, vol. 54, n° 40, p. 5130–5133. doi: 10.1039/c8cc02412j
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Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN1359-7345
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