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Anthrax toxin receptor 2a controls mitotic spindle positioning

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Heisenberg, C. P.
van der Goot, F. G.
Published in Nature cell biology. 2013, vol. 15, no. 1, p. 28-39
Abstract Oriented mitosis is essential during tissue morphogenesis. The Wnt/planar cell polarity (Wnt/PCP) pathway orients mitosis in a number of developmental systems, including dorsal epiblast cell divisions along the animal–vegetal (A–V) axis during zebrafish gastrulation. How Wnt signalling orients the mitotic plane is, however, unknown. Here we show that, in dorsal epiblast cells, anthrax toxin receptor 2a (Antxr2a) accumulates in a polarized cortical cap, which is aligned with the embryonic A–V axis and forecasts the division plane. Filamentous actin (F-actin) also forms an A–V polarized cap, which depends on Wnt/PCP and its effectors RhoA and Rock2. Antxr2a is recruited to the cap by interacting with actin. Antxr2a also interacts with RhoA and together they activate the diaphanous-related formin zDia2. Mechanistically, Antxr2a functions as a Wnt-dependent polarized determinant, which, through the action of RhoA and zDia2, exerts torque on the spindle to align it with the A–V axis.
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Other version: http://www.nature.com/articles/ncb2632
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CASTANON ORTEGA, Irinka et al. Anthrax toxin receptor 2a controls mitotic spindle positioning. In: Nature Cell Biology, 2013, vol. 15, n° 1, p. 28-39. doi: 10.1038/ncb2632 https://archive-ouverte.unige.ch/unige:144350

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Deposited on : 2020-11-09

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