Haploidentical transplantation is associated with better overall survival when compared to single cord blood transplantation: an EBMT-Eurocord study of acute leukemia patients conditioned with thiotepa, busulfan, and fludarabine

Giannotti, Federica; Labopin, Myriam; Shouval, Roni; Sanz, Jaime; Arcese, William; Angelucci, Emanuele; Sierra Hernandez, Jorge Enrique; Santasusana, Josep-Maria Ribera; Santarone, Stella; Benedetto, Bruno; Rambaldi, Alessandro; Saccardi, Riccardo; Blaise, Didier; Carella, Michele Angelo; Rocha, Vanderson; Baron, Frederic; Mohty, Mohamad; Ruggeri, Annalisa; Nagler, Arnon

doi:10.1186/s13045-018-0655-8

Scientific article

Open access

English

Haploidentical transplantation is associated with better overall survival when compared to single cord blood transplantation: an EBMT-Eurocord study of acute leukemia patients conditioned with thiotepa, busulfan, and fludarabine

ContributorsGiannotti, Federica; Labopin, Myriam; Shouval, Roni; Sanz, Jaime; Arcese, William; Angelucci, Emanuele; Sierra Hernandez, Jorge Enrique; Santasusana, Josep-Maria Ribera; Santarone, Stella; Benedetto, Bruno; Rambaldi, Alessandro; Saccardi, Riccardo; Blaise, Didier; Carella, Michele Angelo; Rocha, Vanderson; Baron, Frederic; Mohty, Mohamad; Ruggeri, Annalisa; Nagler, Arnon

Published inJournal of Hematology & Oncology, vol. 11, no. 1, 110

Publication date2018

Abstract

Thiotepa-busulfan-fludarabine (TBF) is a widely used conditioning regimen in single umbilical cord blood transplantation (SUCBT). More recently, it was introduced in the setting of non-T cell depleted haploidentical stem cell transplantation (NTD-Haplo). Whether TBF based conditioning provides additional benefit in transplantation from a particular alternative donor type remains to be established.

Keywords

Adult
Aged
Busulfan/pharmacology/therapeutic use
Cord Blood Stem Cell Transplantation/methods/mortality
Female
Humans
Leukemia, Myeloid, Acute/pathology/therapy
Male
Middle Aged
Retrospective Studies
Survival Rate
Thiotepa/pharmacology/therapeutic use
Transplantation Conditioning/methods/mortality
Transplantation, Haploidentical/methods/mortality
Vidarabine/analogs & derivatives/pharmacology/therapeutic use
Young Adult

Affiliation Not a UNIGE publication

Research group

Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)

Citation (ISO format)

GIANNOTTI, Federica et al. Haploidentical transplantation is associated with better overall survival when compared to single cord blood transplantation: an EBMT-Eurocord study of acute leukemia patients conditioned with thiotepa, busulfan, and fludarabine. In: Journal of Hematology & Oncology, 2018, vol. 11, n° 1, p. 110. doi: 10.1186/s13045-018-0655-8