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Orodigital pemphigus vulgaris: a pathogenic role of anti-desmoglein-3 autoantibodies in pemphigus paronychia?

Published in Dermatology (Basel, Switzerland). 2008, vol. 217, no. 4, p. 337-9
Abstract Paronychia is a rare complication of pemphigus vulgaris (PV), and the immunological profile of patients with digital disease has not been assessed so far. We report 2 cases of PV with oral mucosa and periungual involvement, who had high titers of anti- desmoglein (Dsg)-3 circulating antibodies. These observations raise the possibility that expression of Dsg-1 and Dsg-3 in distinct areas of periungual skin is disease specific and that anti-Dsg-3 antibodies alone may have an as yet unrecognized importance for the development of paronychia in PV.
Keywords AgedAutoantibodies/bloodBiological Markers/bloodDesmoglein 1/immunologyDesmoglein 3/immunologyEnzyme-Linked Immunosorbent AssayFemaleFingersHumansMiddle AgedMouth Diseases/immunology/pathologyMouth Mucosa/pathologyParonychia/immunologyPemphigus/immunology/pathologyToes
Stable URL https://archive-ouverte.unige.ch/unige:1442
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PMID: 18799879

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Deposited on : 2009-04-28

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