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Scientific article
English

Orodigital pemphigus vulgaris: a pathogenic role of anti-desmoglein-3 autoantibodies in pemphigus paronychia?

Published inDermatology, vol. 217, no. 4, p. 337-339
Publication date2008
Abstract

Paronychia is a rare complication of pemphigus vulgaris (PV), and the immunological profile of patients with digital disease has not been assessed so far. We report 2 cases of PV with oral mucosa and periungual involvement, who had high titers of anti- desmoglein (Dsg)-3 circulating antibodies. These observations raise the possibility that expression of Dsg-1 and Dsg-3 in distinct areas of periungual skin is disease specific and that anti-Dsg-3 antibodies alone may have an as yet unrecognized importance for the development of paronychia in PV.

Keywords
  • Aged
  • Autoantibodies/blood
  • Biological Markers/blood
  • Desmoglein 1/immunology
  • Desmoglein 3/immunology
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fingers
  • Humans
  • Middle Aged
  • Mouth Diseases/immunology/pathology
  • Mouth Mucosa/pathology
  • Paronychia/immunology
  • Pemphigus/immunology/pathology
  • Toes
Citation (ISO format)
LAFFITTE, Emmanuel Alexis, PANIZZON, Renato, BORRADORI, Luca. Orodigital pemphigus vulgaris: a pathogenic role of anti-desmoglein-3 autoantibodies in pemphigus paronychia? In: Dermatology, 2008, vol. 217, n° 4, p. 337–339. doi: 10.1159/000155645
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Article (Accepted version)
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ISSN of the journal1018-8665
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