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Vitamin D supplementation: upper limit for safety revisited?

Published in Aging Clinical and Experimental Research. 2020
Abstract Vitamin D overdosing includes hypercalcemia, hypercalciuria, and mineral deposits in soft tissues. A safety upper limit of 4000 IU/day, which is consistently accepted, has been challenged, since the risk of adverse events in other systems than calcium-phosphate homeostasis may depend not only on the dose, but on the outcome, the treatment regimen, and possibly the age, sex and vitamin D status. The therapeutic window of vitamin D supplementation may be narrower than hitherto recognized. The prevention and/or correction of vitamin D deficiency/insufficiency with 800-1000 IU/daily of vitamin D or 10 µg/day of calcifediol are safe. Because of their potential harm, larger doses given on the long term or in intermittent regimens should not be selected.
Keywords Bone healthFallsFractureOsteoporosisSarcopenia
PMID: 32857334
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Research group Génétique des ostéoporoses (544)
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RIZZOLI, René. Vitamin D supplementation: upper limit for safety revisited?. In: Aging Clinical and Experimental Research, 2020. doi: 10.1007/s40520-020-01678-x https://archive-ouverte.unige.ch/unige:143946

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Deposited on : 2020-11-02

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