Scientific article
Open access

Vitamin D supplementation: upper limit for safety revisited?

ContributorsRizzoli, René
Publication date2020

Vitamin D overdosing includes hypercalcemia, hypercalciuria, and mineral deposits in soft tissues. A safety upper limit of 4000 IU/day, which is consistently accepted, has been challenged, since the risk of adverse events in other systems than calcium-phosphate homeostasis may depend not only on the dose, but on the outcome, the treatment regimen, and possibly the age, sex and vitamin D status. The therapeutic window of vitamin D supplementation may be narrower than hitherto recognized. The prevention and/or correction of vitamin D deficiency/insufficiency with 800-1000 IU/daily of vitamin D or 10 µg/day of calcifediol are safe. Because of their potential harm, larger doses given on the long term or in intermittent regimens should not be selected.

  • Bone health
  • Falls
  • Fracture
  • Osteoporosis
  • Sarcopenia
Citation (ISO format)
RIZZOLI, René. Vitamin D supplementation: upper limit for safety revisited? In: Aging Clinical and Experimental Research, 2020. doi: 10.1007/s40520-020-01678-x
Main files (1)
Article (Published version)
ISSN of the journal1594-0667

Technical informations

Creation09/08/2020 2:07:00 PM
First validation09/08/2020 2:07:00 PM
Update time03/15/2023 10:55:37 PM
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