Article (Published version) (421 Kb) - 
Free accessOther version: http://link.springer.com/10.1007/s40520-020-01678-x
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Scientific Article - Review
unige:143946 
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Vitamin D supplementation: upper limit for safety revisited? |
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| Author | ||
| Published in | Aging Clinical and Experimental Research. 2020 | |
| Abstract | Vitamin D overdosing includes hypercalcemia, hypercalciuria, and mineral deposits in soft tissues. A safety upper limit of 4000 IU/day, which is consistently accepted, has been challenged, since the risk of adverse events in other systems than calcium-phosphate homeostasis may depend not only on the dose, but on the outcome, the treatment regimen, and possibly the age, sex and vitamin D status. The therapeutic window of vitamin D supplementation may be narrower than hitherto recognized. The prevention and/or correction of vitamin D deficiency/insufficiency with 800-1000 IU/daily of vitamin D or 10 µg/day of calcifediol are safe. Because of their potential harm, larger doses given on the long term or in intermittent regimens should not be selected. | |
| Keywords | Bone health — Falls — Fracture — Osteoporosis — Sarcopenia | |
| Identifiers | PMID: 32857334 | |
| Full text |
Article (Published version) (421 Kb) - Free access Other version: http://link.springer.com/10.1007/s40520-020-01678-x |
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| Structures | ||
| Research group | Génétique des ostéoporoses (544) | |
| Citation (ISO format) | RIZZOLI, René. Vitamin D supplementation: upper limit for safety revisited?. In: Aging Clinical and Experimental Research, 2020. doi: 10.1007/s40520-020-01678-x https://archive-ouverte.unige.ch/unige:143946 |
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