Article (Published version) (421 Kb) - Free access
Other version: http://link.springer.com/10.1007/s40520-020-01678-x
Vitamin D supplementation: upper limit for safety revisited?
|Published in||Aging Clinical and Experimental Research. 2020|
|Abstract||Vitamin D overdosing includes hypercalcemia, hypercalciuria, and mineral deposits in soft tissues. A safety upper limit of 4000 IU/day, which is consistently accepted, has been challenged, since the risk of adverse events in other systems than calcium-phosphate homeostasis may depend not only on the dose, but on the outcome, the treatment regimen, and possibly the age, sex and vitamin D status. The therapeutic window of vitamin D supplementation may be narrower than hitherto recognized. The prevention and/or correction of vitamin D deficiency/insufficiency with 800-1000 IU/daily of vitamin D or 10 µg/day of calcifediol are safe. Because of their potential harm, larger doses given on the long term or in intermittent regimens should not be selected.|
|Keywords||Bone health — Falls — Fracture — Osteoporosis — Sarcopenia|
|Research group||Génétique des ostéoporoses (544)|
|RIZZOLI, René. Vitamin D supplementation: upper limit for safety revisited?. In: Aging Clinical and Experimental Research, 2020. doi: 10.1007/s40520-020-01678-x https://archive-ouverte.unige.ch/unige:143946|