Macrophage activation syndrome as an unusual presentation of paucisymptomatic severe acute respiratory syndrome coronavirus 2 infection: A case report

Lolachi, Sanaz; Morin, Sarah; Coen, Matteo; Samii, Kaveh; Calmy, Alexandra; Serratrice, Jacques

doi:10.1097/MD.0000000000021570

Scientific article

Case report

English

Macrophage activation syndrome as an unusual presentation of paucisymptomatic severe acute respiratory syndrome coronavirus 2 infection: A case report

ContributorsLolachi, Sanaz; Morin, Sarah; Coen, Matteo

; Samii, Kaveh; Calmy, Alexandra

; Serratrice, Jacques

Published inMedicine (Baltimore), vol. 99, no. 32, e21570

Publication date2020

Abstract

Macrophage activation syndrome (MAS) is a rare life-threatening condition characterized by cytokine-mediated tissue injury and multiorgan dysfunction. We describe the unique case of young man who developed MAS as the sole manifestation of an otherwise paucisymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Keywords

Adolescent
Blood Chemical Analysis
Ceftriaxone/administration & dosage
China
Clinical Laboratory Techniques/methods
Coronavirus Infections/diagnosis/drug therapy
DNA, Viral/analysis
Diagnosis, Differential
Disease Progression
Drug Therapy, Combination
Electrocardiography/methods
Follow-Up Studies
Hospitalization
Humans
Hydroxychloroquine/administration & dosage
Macrophage Activation Syndrome/diagnosis/therapy
Male
Pandemics
Patient Discharge
Pneumonia, Viral/diagnosis/drug therapy
Radiography, Thoracic/methods
Real-Time Polymerase Chain Reaction/methods
Risk Assessment
Severity of Illness Index
Tomography, X-Ray Computed/methods
Treatment Outcome
Coronavirus
Hydroxychloroquine
Hyper-inflammation
Interleukin-6
Macrophages

Affiliation entities

Research groups

Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)

Citation (ISO format)

LOLACHI, Sanaz et al. Macrophage activation syndrome as an unusual presentation of paucisymptomatic severe acute respiratory syndrome coronavirus 2 infection: A case report. In: Medicine (Baltimore), 2020, vol. 99, n° 32, p. e21570. doi: 10.1097/MD.0000000000021570