UNIGE document Scientific Article
previous document  unige:143932  next document
add to browser collection
Title

Withdrawal symptoms from e-cigarette abstinence among adult never-smokers: a pilot experimental study

Authors
Hughes, John R
Peters, Erica N
Callas, Peter W
Peasley-Miklus, Catherine
Oga, Emmanuel
Morley, Nicholas
Published in Nicotine & Tobacco Research. 2020, vol. 22, no. 5, p. 740-746
Abstract Introduction: Use of e-cigarettes among never-smokers has substantially increased; yet there are few descriptions of the consequences of such use. We assessed whether adult never-smokers can have withdrawal from cessation of e-cigarettes. Methods: In an un-blinded pre-post clinical trial, 30 never-smoker daily e-cigarette users used their own nicotine-containing e-cigarette for 7 days followed by 6 days of biologically confirmed abstinence. Participants monitored symptoms of nicotine withdrawal nightly via an Interactive Voice Response system. They attended three lab visits/week to provide expired carbon monoxide and urine samples to determine compliance. Findings: Abstinence increased all the DSM5 symptoms of tobacco withdrawal and this occurred in the majority of participants. The increase in severity of withdrawal was small and rarely impaired functioning. Conclusions: Our finding suggests that withdrawal symptoms can occur in never-smokers who stop e-cigarettes abruptly. However, the severity of withdrawal appears to be small and may not be of clinical or regulatory significance. Although our sample size was small and thus replication tests of our results are indicated, it may be prudent to warn never-smokers that withdrawal symptoms may occur. Implications: This study indicates that withdrawal symptoms can occur in never-smokers who are daily e-cigarette users. However, the severity of withdrawal from e-cigarette abstinence in never-smokers appears to be small and may not be of clinical or regulatory significance. Given our small sample size, replication of our results is warranted. Nevertheless, it might be prudent to warn never-smokers of addiction to e-cigarettes.Clinical Trial Registration = NCT02825459.
Identifiers
PMID: 31504882
Full text
Structures
Research group Programme de recherche sur le tabagisme (117)
Citation
(ISO format)
HUGHES, John R et al. Withdrawal symptoms from e-cigarette abstinence among adult never-smokers: a pilot experimental study. In: Nicotine & Tobacco Research, 2020, vol. 22, n° 5, p. 740-746. doi: 10.1093/ntr/ntz169 https://archive-ouverte.unige.ch/unige:143932

39 hits

27 downloads

Update

Deposited on : 2020-11-02

Export document
Format :
Citation style :