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Title

Clinical method evaluation of hemoglobin S and C identification by top-down selected reaction monitoring and electron transfer dissociation

Authors
Hartmer, Ralf
Jabs, Wolfgang
Tsybin, Yury O
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Published in Clinical proteomics. 2019, vol. 16, 41
Abstract Biological diagnosis of hemoglobin disorders is a complex process relying on the combination of several analytical techniques to identify Hb variants in a particular sample. Currently, hematology laboratories usually use high-performance liquid chromatography (HPLC), capillary electrophoresis and gel-based methods to characterize Hb variants. Co-elution and co-migration may represent major issues for precise identification of Hb variants, even for the most common ones such as Hb S and C.
Keywords ETDElectron transfer dissociationHemoglobinHemoglobin disordersHemoglobin variantIntact proteinSRMSelected reaction monitoringTop-down
Identifiers
PMID: 31889938
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Structures
Research groups Chimie et protéomique clinique (270)
Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)
Projects
Swiss National Science Foundation: 32003B_143809
Autre: Fondation Ernst et Lucie Schmidheiny
Citation
(ISO format)
LASSOUT, Olivier et al. Clinical method evaluation of hemoglobin S and C identification by top-down selected reaction monitoring and electron transfer dissociation. In: Clinical Proteomics, 2019, vol. 16, p. 41. doi: 10.1186/s12014-019-9261-1 https://archive-ouverte.unige.ch/unige:143926

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Deposited on : 2020-11-02

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