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Scientific article
Open access
English

Clinical method evaluation of hemoglobin S and C identification by top-down selected reaction monitoring and electron transfer dissociation

Published inClinical Proteomics, vol. 16, 41
Publication date2019
Abstract

Biological diagnosis of hemoglobin disorders is a complex process relying on the combination of several analytical techniques to identify Hb variants in a particular sample. Currently, hematology laboratories usually use high-performance liquid chromatography (HPLC), capillary electrophoresis and gel-based methods to characterize Hb variants. Co-elution and co-migration may represent major issues for precise identification of Hb variants, even for the most common ones such as Hb S and C.

Keywords
  • ETD
  • Electron transfer dissociation
  • Hemoglobin
  • Hemoglobin disorders
  • Hemoglobin variant
  • Intact protein
  • SRM
  • Selected reaction monitoring
  • Top-down
Citation (ISO format)
LASSOUT, Olivier et al. Clinical method evaluation of hemoglobin S and C identification by top-down selected reaction monitoring and electron transfer dissociation. In: Clinical Proteomics, 2019, vol. 16, p. 41. doi: 10.1186/s12014-019-9261-1
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Article (Published version)
Identifiers
ISSN of the journal1542-6416
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Technical informations

Creation10/27/2020 4:48:00 PM
First validation10/27/2020 4:48:00 PM
Update time03/15/2023 10:55:04 PM
Status update03/15/2023 10:55:03 PM
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