Stable HIV-1 reservoirs on dolutegravir maintenance monotherapy: the MONODO study

Sculier, Delphine; Doco-Lecompte, T; Yerly Ferrillo, Sabine; Metzner, K J; Decosterd, L A; Calmy, Alexandra

doi:10.1111/hiv.12626

Scientific article

Open access

English

Stable HIV-1 reservoirs on dolutegravir maintenance monotherapy: the MONODO study

ContributorsSculier, Delphine; Doco-Lecompte, T; Yerly Ferrillo, Sabine; Metzner, K J; Decosterd, L A; Calmy, Alexandra

Published inHIV Medicine, vol. 19, no. 8, p. 572-577

Publication date2018

Abstract

Dolutegravir (DTG) is a highly effective integrase inhibitor with a strong genetic resistance barrier and a potential role in simplified HIV maintenance treatment. We assessed the feasibility of DTG maintenance monotherapy and measured HIV reservoirs on DTG monotherapy.

Keywords

HIV
HIV reservoirs
Dolutegravir
Maintenance therapy
Simplification

Affiliation

Faculté de médecine / Section de médecine clinique / Département de médecine

Research group

Funding

Swiss National Science Foundation - 324730‐165956

Citation (ISO format)

SCULIER, Delphine et al. Stable HIV-1 reservoirs on dolutegravir maintenance monotherapy: the MONODO study. In: HIV Medicine, 2018, vol. 19, n° 8, p. 572–577. doi: 10.1111/hiv.12626

Article (Published version)

CC BY-NC-ND

Identifiers

PID : unige:143779
DOI : 10.1111/hiv.12626
PMID : 29932298

Commercial URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120531/

ISSN of the journal1464-2662

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Stable HIV-1 reservoirs on dolutegravir maintenance monotherapy: the MONODO study

Dolutegravir (DTG) is a highly effective integrase inhibitor with a strong genetic resistance barrier and a potential role in simplified HIV maintenance treatment. We assessed the feasibility of DTG maintenance monotherapy and measured HIV reservoirs on DTG monotherapy.

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