en
Scientific article
English

Growth control by a moving morphogen gradient during Drosophila eye development

Published inDevelopment, vol. 141, no. 9, p. 1884-1893
Publication date2014
Abstract

During morphogenesis, organs grow to stereotyped sizes, but growth control mechanisms are poorly understood. Here, we measured the signaling dynamics of the morphogen Dpp, one of several Drosophila factors controlling morphogenetic growth, in the developing eye. In this tissue, the Dpp expression domain advances from the posterior to the anterior tissue edge. In front of this moving morphogen source, signaling inputs including Dpp activate the target gene hairy in a gradient that scales with tissue size. Proliferation, in turn, occurs in a mitotic wave in front of the source, whereas behind it, cells arrest and differentiate. We found that cells divide when their signaling levels have increased by around 60%. This simple mechanism quantitatively explains the proliferation and differentiation waves in wild type and mutants. Furthermore, this mechanism may be a common feature of different growth factors, because a Dpp-independent growth input also follows this growth rule.

Keywords
  • Eye
  • Development
  • Drosophila
  • Morphogen
  • Growth
  • Models
  • Biophysics
Citation (ISO format)
WARTLICK, Ortrud, JÜLICHER, Frank, GONZALEZ GAITAN, Marcos. Growth control by a moving morphogen gradient during Drosophila eye development. In: Development, 2014, vol. 141, n° 9, p. 1884–1893. doi: 10.1242/dev.105650
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0950-1991
172views
1downloads

Technical informations

Creation10/13/2020 4:42:00 PM
First validation10/13/2020 4:42:00 PM
Update time03/15/2023 10:52:56 PM
Status update03/15/2023 10:52:56 PM
Last indexation01/17/2024 11:17:14 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack