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Title

PDGF receptor signaling in osteoblast lineage cells controls bone resorption through upregulation of csf1 expression

Authors
Andreasen, Christina Møller
Ejersted, Charlotte
Andersen, Thomas Levin
Published in Journal of bone and mineral research. 2020
Abstract The physiological functions of platelet-derived growth factor receptors (PDGFRs) α and β in osteoblast biology and bone metabolism remain to be established. Here, we show that PDGFRA and PDGFRB genes are expressed by osteoblast-lineage canopy and reversal cells in close proximity to PDGFB-expressing osteoclasts within human trabecular bone remodeling units. We also report that, although removal of only one of the two PDGFRs in Osterix-positive cells does not affect bone phenotype, suppression of both PDGFRs in those osteoblast lineage cells increases trabecular bone volume in male mice as well as in female gonad-intact and ovariectomized mice. [...]
Keywords Bone ResorptionERK1/2M-CsfOsteoblast Lineage CellsPDGF Receptors
Identifiers
PMID: 32777109
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Article (Published version) (2.6 MB) - document accessible for UNIGE members only Limited access to UNIGE
Supplemental data (534 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: https://onlinelibrary.wiley.com/doi/abs/10.1002/jbmr.4150
Structures
Research group Génétique des ostéoporoses (544)
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BRUN, Julia et al. PDGF receptor signaling in osteoblast lineage cells controls bone resorption through upregulation of csf1 expression. In: Journal of Bone and Mineral Research, 2020. doi: 10.1002/jbmr.4150 https://archive-ouverte.unige.ch/unige:143609

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Deposited on : 2020-10-28

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