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Scientific article
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PDGF receptor signaling in osteoblast lineage cells controls bone resorption through upregulation of csf1 expression

Publication date2020
Abstract

The physiological functions of platelet-derived growth factor receptors (PDGFRs) α and β in osteoblast biology and bone metabolism remain to be established. Here, we show that PDGFRA and PDGFRB genes are expressed by osteoblast-lineage canopy and reversal cells in close proximity to PDGFB-expressing osteoclasts within human trabecular bone remodeling units. We also report that, although removal of only one of the two PDGFRs in Osterix-positive cells does not affect bone phenotype, suppression of both PDGFRs in those osteoblast lineage cells increases trabecular bone volume in male mice as well as in female gonad-intact and ovariectomized mice. [...]

Keywords
  • Bone Resorption
  • ERK1/2
  • M-Csf
  • Osteoblast Lineage Cells
  • PDGF Receptors
Citation (ISO format)
BRUN, Julia et al. PDGF receptor signaling in osteoblast lineage cells controls bone resorption through upregulation of csf1 expression. In: Journal of Bone and Mineral Research, 2020. doi: 10.1002/jbmr.4150
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Identifiers
ISSN of the journal0884-0431
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Creation09/22/2020 11:42:00 AM
First validation09/22/2020 11:42:00 AM
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