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Title

Maternal antibodies inhibit neonatal and infant responses to vaccination by shaping the early-life B cell repertoire within germinal centers

Authors
Christensen, Dennis
Andersen, Peter
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Published in Cell Reports. 2019, vol. 28, no. 7, p. 1773-1784.e5
Abstract Maternal antibodies (MatAbs) protect offspring from infections but limit their responses to vaccination. The mechanisms of this inhibition are still debated. Using murine early-life immunization models mimicking the condition prevailing in humans, we observed the induction of CD4-T, T follicular helper, and germinal center (GC) B cell responses even when early-life antibody responses were abrogated by MatAbs. GC B cells induced in the presence of MatAbs form GC structures and exhibit canonical GC changes in gene expression but fail to differentiate into plasma cells and/or memory B cells in a MatAb titer-dependent manner. Furthermore, GC B cells elicited in the presence or absence of MatAbs use different VH and Vk genes and show differences in genes associated with B cell differentiation and isotype switching. Thus, MatAbs do not prevent B cell activation but control the output of the GC reaction both quantitatively and qualitatively, shaping the antigen-specific B cell repertoire.
Keywords AnimalsNewbornAntibodies/blood/immunologyAntibodiesViral/blood/immunologyAntibody Formation/immunologyB-Lymphocytes/immunologyFemaleGerminal Center/immunologyImmunizationMaleMaternal-Fetal Exchange/immunologyMiceInbred BALB CInbred C57BLOrthomyxoviridae/immunologyOrthomyxoviridae Infections/immunology/virologyPregnancyT-LymphocytesHelper-Inducer/immunologyVaccination
Identifiers
PMID: 31412246
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Structures
Research group Centre de vaccinologie et d'immunologie néonatale (177)
Projects
FNS: 310000-111926/1; 310030-165960
FP7: ADITEC
Citation
(ISO format)
VONO, Maria et al. Maternal antibodies inhibit neonatal and infant responses to vaccination by shaping the early-life B cell repertoire within germinal centers. In: Cell Reports, 2019, vol. 28, n° 7, p. 1773-1784.e5. doi: 10.1016/j.celrep.2019.07.047 https://archive-ouverte.unige.ch/unige:143451

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Deposited on : 2020-10-23

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