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Title

Neonatal T follicular helper cells are lodged in a pre-T follicular helper stage favoring innate over adaptive germinal center responses

Authors
Gonzalez-Dias, Patrícia
Ferreira, Frederico Moraes
Cardozo, Lucas
Nakaya, Helder I
Published in Frontiers in Immunology. 2019, vol. 10, p. 1845
Abstract T follicular helper (Tfh) cells have emerged as a critical limiting factor for controlling the magnitude of neonatal germinal center (GC) reactions and primary vaccine antibody responses. We compared the functional attributes of neonatal and adult Tfh cells at the transcriptomic level and demonstrated that the Tfh cell program is well-initiated in neonates although the Tfh gene-expression pattern (i.e., CXCR5, IL-21, BCL6, TBK1, STAT4, ASCL2, and c-MAF) is largely underrepresented as compared to adult Tfh cells. Importantly, we identified a TH2-bias of neonatal Tfh cells, with preferential differentiation toward short-lived pre-Tfh effector cells. Remarkably, adjuvantation with CpG-ODNs redirect neonatal pre-Tfh cells toward committed GC-Tfh cells, as illustrated by increased expression of Tfh signature genes and reduced expression of TH2-related genes.
Keywords Adaptive ImmunityAdjuvantsImmunologicAging/immunologyAnimalsNewborn/immunologyGerminal Center/cytology/immunologyImmunityInnateInterleukin-13/metabolismLymphopoiesis/geneticsMiceInbred C57BLT-LymphocytesHelper-Inducer/immunologyTh2 Cells/cytology/immunologyTranscriptome
Identifiers
PMID: 31456798
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Structures
Research group Centre de vaccinologie et d'immunologie néonatale (177)
Projects FNS: 310000-111926/1
FNS: 310030-165960
Citation
(ISO format)
MASTELIC-GAVILLET, Beatris et al. Neonatal T follicular helper cells are lodged in a pre-T follicular helper stage favoring innate over adaptive germinal center responses. In: Frontiers in Immunology, 2019, vol. 10, p. 1845. doi: 10.3389/fimmu.2019.01845 https://archive-ouverte.unige.ch/unige:143450

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Deposited on : 2020-10-23

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