Temporal sharpening of sensory responses by layer V in the mouse primary somatosensory cortex

Vecchia, Dania; Beltramo, Riccardo; Vallone, Fabio; Chereau, Ronan; Forli, Angelo; Molano-Mazón, Manuel; Bawa, Tanika; Binini, Noemi; Moretti, Claudio; Holtmaat, Anthony; Panzeri, Stefano; Fellin, Tommaso

doi:10.1016/j.cub.2020.02.004

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Title		Temporal sharpening of sensory responses by layer V in the mouse primary somatosensory cortex
Authors		Vecchia, Dania Beltramo, Riccardo Vallone, Fabio Chereau, Ronan Forli, Angelo Molano-Mazón, Manuel Bawa, Tanika Binini, Noemi Moretti, Claudio Holtmaat, Anthony Panzeri, Stefano Fellin, Tommaso show all authors [1 - 12]
Published in		Current Biology. 2020, vol. 30, no. 9, p. 1589-1599.e10
Abstract		The timing of stimulus-evoked spikes encodes information about sensory stimuli. Here we studied the neural circuits controlling this process in the mouse primary somatosensory cortex. We found that brief optogenetic activation of layer V pyramidal cells just after whisker deflection modulated the membrane potential of neurons and interrupted their long-latency whisker responses, increasing their accuracy in encoding whisker deflection time. In contrast, optogenetic inhibition of layer V during either passive whisker deflection or active whisking decreased accuracy in encoding stimulus or touch time, respectively. Suppression of layer V pyramidal cells increased reaction times in a texture discrimination task. Moreover, two-color optogenetic experiments revealed that cortical inhibition was efficiently recruited by layer V stimulation and that it mainly involved activation of parvalbumin-positive rather than somatostatin-positive interneurons. Layer V thus performs behaviorally relevant temporal sharpening of sensory responses through circuit-specific recruitment of cortical inhibition.
Identifiers		DOI: 10.1016/j.cub.2020.02.004 PMID: 32169206
Full text		Article (Published version) (6.7 MB) - Free access Other version: https://linkinghub.elsevier.com/retrieve/pii/S0960982220301779
Structures		Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales
Research group		Les circuits neuronaux dans le néocortex des mammifères (855)
Projects		FNS: 31003A-153448 ; 31003A_173125 ; CRSII3_154453; NCCR Synapsy 51NF40-158776 IRP
Citation (ISO format)		VECCHIA, Dania et al. Temporal sharpening of sensory responses by layer V in the mouse primary somatosensory cortex. In: Current Biology, 2020, vol. 30, n° 9, p. 1589-1599.e10. doi: 10.1016/j.cub.2020.02.004 https://archive-ouverte.unige.ch/unige:143400