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Scientific article
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Temporal sharpening of sensory responses by layer V in the mouse primary somatosensory cortex

Published inCurrent Biology, vol. 30, no. 9, p. 1589-1599.e10
Publication date2020
Abstract

The timing of stimulus-evoked spikes encodes information about sensory stimuli. Here we studied the neural circuits controlling this process in the mouse primary somatosensory cortex. We found that brief optogenetic activation of layer V pyramidal cells just after whisker deflection modulated the membrane potential of neurons and interrupted their long-latency whisker responses, increasing their accuracy in encoding whisker deflection time. In contrast, optogenetic inhibition of layer V during either passive whisker deflection or active whisking decreased accuracy in encoding stimulus or touch time, respectively. Suppression of layer V pyramidal cells increased reaction times in a texture discrimination task. Moreover, two-color optogenetic experiments revealed that cortical inhibition was efficiently recruited by layer V stimulation and that it mainly involved activation of parvalbumin-positive rather than somatostatin-positive interneurons. Layer V thus performs behaviorally relevant temporal sharpening of sensory responses through circuit-specific recruitment of cortical inhibition.

Citation (ISO format)
VECCHIA, Dania et al. Temporal sharpening of sensory responses by layer V in the mouse primary somatosensory cortex. In: Current Biology, 2020, vol. 30, n° 9, p. 1589–1599.e10. doi: 10.1016/j.cub.2020.02.004
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ISSN of the journal0960-9822
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Creation10/12/2020 10:18:00 AM
First validation10/12/2020 10:18:00 AM
Update time03/15/2023 10:49:25 PM
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