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Temporal sharpening of sensory responses by layer V in the mouse primary somatosensory cortex

Vecchia, Dania
Beltramo, Riccardo
Vallone, Fabio
Forli, Angelo
Molano-Mazón, Manuel
Binini, Noemi
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Published in Current Biology. 2020, vol. 30, no. 9, p. 1589-1599.e10
Abstract The timing of stimulus-evoked spikes encodes information about sensory stimuli. Here we studied the neural circuits controlling this process in the mouse primary somatosensory cortex. We found that brief optogenetic activation of layer V pyramidal cells just after whisker deflection modulated the membrane potential of neurons and interrupted their long-latency whisker responses, increasing their accuracy in encoding whisker deflection time. In contrast, optogenetic inhibition of layer V during either passive whisker deflection or active whisking decreased accuracy in encoding stimulus or touch time, respectively. Suppression of layer V pyramidal cells increased reaction times in a texture discrimination task. Moreover, two-color optogenetic experiments revealed that cortical inhibition was efficiently recruited by layer V stimulation and that it mainly involved activation of parvalbumin-positive rather than somatostatin-positive interneurons. Layer V thus performs behaviorally relevant temporal sharpening of sensory responses through circuit-specific recruitment of cortical inhibition.
PMID: 32169206
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Research group Les circuits neuronaux dans le néocortex des mammifères (855)
Swiss National Science Foundation: 31003A_153448
Swiss National Science Foundation: 31003A_173125
Swiss National Science Foundation: CRSII3_154453
Swiss National Science Foundation: 31003A-153448 ; 31003A_173125 ; CRSII3_154453; NCCR Synapsy 51NF40-158776
Autre: IRP
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VECCHIA, Dania et al. Temporal sharpening of sensory responses by layer V in the mouse primary somatosensory cortex. In: Current Biology, 2020, vol. 30, n° 9, p. 1589-1599.e10. doi: 10.1016/j.cub.2020.02.004 https://archive-ouverte.unige.ch/unige:143400

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Deposited on : 2020-10-21

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