

Other version: https://linkinghub.elsevier.com/retrieve/pii/S0960982220301779
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Temporal sharpening of sensory responses by layer V in the mouse primary somatosensory cortex |
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Authors | ![]() | |
Published in | Current Biology. 2020, vol. 30, no. 9, p. 1589-1599.e10 | |
Abstract | The timing of stimulus-evoked spikes encodes information about sensory stimuli. Here we studied the neural circuits controlling this process in the mouse primary somatosensory cortex. We found that brief optogenetic activation of layer V pyramidal cells just after whisker deflection modulated the membrane potential of neurons and interrupted their long-latency whisker responses, increasing their accuracy in encoding whisker deflection time. In contrast, optogenetic inhibition of layer V during either passive whisker deflection or active whisking decreased accuracy in encoding stimulus or touch time, respectively. Suppression of layer V pyramidal cells increased reaction times in a texture discrimination task. Moreover, two-color optogenetic experiments revealed that cortical inhibition was efficiently recruited by layer V stimulation and that it mainly involved activation of parvalbumin-positive rather than somatostatin-positive interneurons. Layer V thus performs behaviorally relevant temporal sharpening of sensory responses through circuit-specific recruitment of cortical inhibition. | |
Identifiers | PMID: 32169206 | |
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![]() ![]() Other version: https://linkinghub.elsevier.com/retrieve/pii/S0960982220301779 |
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Structures | ||
Research group | Les circuits neuronaux dans le néocortex des mammifères (855) | |
Projects | Swiss National Science Foundation: 31003A_153448 Swiss National Science Foundation: 31003A_173125 Swiss National Science Foundation: CRSII3_154453 Swiss National Science Foundation: 31003A-153448 ; 31003A_173125 ; CRSII3_154453; NCCR Synapsy 51NF40-158776 Autre: IRP | |
Citation (ISO format) | VECCHIA, Dania et al. Temporal sharpening of sensory responses by layer V in the mouse primary somatosensory cortex. In: Current Biology, 2020, vol. 30, n° 9, p. 1589-1599.e10. doi: 10.1016/j.cub.2020.02.004 https://archive-ouverte.unige.ch/unige:143400 |