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Title

Histone exchange is associated with activator function at transcribed promoters and with repression at histone loci

Authors
Hughes, Amanda L
Rando, Oliver J
Published in Science Advances. 2020, vol. 6, no. 36, eabb0333
Abstract Transcription in eukaryotes correlates with major chromatin changes, including the replacement of old nucleosomal histones by new histones at the promoters of genes. The role of these histone exchange events in transcription remains unclear. In particular, the causal relationship between histone exchange and activator binding, preinitiation complex (PIC) assembly, and/or subsequent transcription remains unclear. Here, we provide evidence that histone exchange at gene promoters is not simply a consequence of PIC assembly or transcription but instead is mediated by activators. We further show that not all activators up-regulate gene expression by inducing histone turnover. Thus, histone exchange does not simply correlate with transcriptional activity, but instead reflects the mode of action of the activator. Last, we show that histone turnover is not only associated with activator function but also plays a role in transcriptional repression at the histone loci.
Identifiers
PMID: 32917590
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Structures
Research group Régulation de l'expression des gènes du virus de l'hépatite B (294)
Projects FNS: 310030-175781
FNS: 310030-149626
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(ISO format)
KASSEM, Sari et al. Histone exchange is associated with activator function at transcribed promoters and with repression at histone loci. In: Science Advances, 2020, vol. 6, n° 36, p. eabb0333. doi: 10.1126/sciadv.abb0333 https://archive-ouverte.unige.ch/unige:143270

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Deposited on : 2020-10-19

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