Effect of ivabradine on major adverse cardiovascular events and mortality in critically ill patients: a systematic review and meta-analyses of randomised controlled trials with trial sequential analyses

Chen, Aileen; Elia, Nadia; Dunaiceva, Jelena; Rudiger, Alain; Walder, Bernard; Bollen Pinto, Bernardo

doi:10.1016/j.bja.2020.01.027

Scientific article

Meta-analysis

English

Effect of ivabradine on major adverse cardiovascular events and mortality in critically ill patients: a systematic review and meta-analyses of randomised controlled trials with trial sequential analyses

ContributorsChen, Aileen; Elia, Nadia

; Dunaiceva, Jelena; Rudiger, Alain; Walder, Bernard; Bollen Pinto, Bernardo

Published inBritish Journal of Anaesthesia, vol. 124, no. 6, p. 726-738

Publication date2020

Abstract

Ivabradine lowers heart rate (HR) without affecting contractility or vascular tone. It is licensed for HR control in chronic heart diseases. We performed a systematic review and meta-analyses to examine whether ivabradine could decrease major adverse cardiovascular events (MACE) and mortality in critically ill patients.

Keywords

Cardiovascular Agents/therapeutic use
Critical Illness
Heart Diseases/drug therapy/mortality/physiopathology
Humans
Ivabradine/therapeutic use
Treatment Outcome

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

Research groups

Groupe de recherche en hémodynamique (913)

Citation (ISO format)

CHEN, Aileen et al. Effect of ivabradine on major adverse cardiovascular events and mortality in critically ill patients: a systematic review and meta-analyses of randomised controlled trials with trial sequential analyses. In: British Journal of Anaesthesia, 2020, vol. 124, n° 6, p. 726–738. doi: 10.1016/j.bja.2020.01.027

Article (Published version)

Supplemental data

Identifiers

PID : unige:143201
DOI : 10.1016/j.bja.2020.01.027
PMID : 32147100

Journal ISSN0007-0912

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Creation12/08/2020 17:04:00

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Update27/06/2024 08:59:49

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Effect of ivabradine on major adverse cardiovascular events and mortality in critically ill patients: a systematic review and meta-analyses of randomised controlled trials with trial sequential analyses

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