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Scientific article
Open access
English

Influenza A virus infection impacts systemic microbiota dynamics and causes quantitative enteric dysbiosis

Published inMicrobiome, vol. 6, no. 1, 9
Publication date2018
Abstract

Microbiota integrity is essential for a growing number of physiological processes. Consequently, disruption of microbiota homeostasis correlates with a variety of pathological states. Importantly, commensal microbiota provide a shield against invading bacterial pathogens, probably by direct competition. The impact of viral infections on host microbiota composition and dynamics is poorly understood. Influenza A viruses (IAV) are common respiratory pathogens causing acute infections. Here, we show dynamic changes in respiratory and intestinal microbiota over the course of a sublethal IAV infection in a mouse model.

Keywords
  • Animals
  • Bacteria/classification/genetics/isolation & purification
  • DNA
  • Bacterial/genetics
  • DNA
  • Ribosomal/genetics
  • Disease Models
  • Animal
  • Dysbiosis/microbiology
  • Female
  • Gastrointestinal Microbiome
  • Influenza A virus/pathogenicity
  • Mice
  • Orthomyxoviridae Infections/microbiology
  • Paneth Cells/microbiology
  • RNA
  • Ribosomal
  • 16S/genetics
  • Sequence Analysis
  • DNA
Citation (ISO format)
YILDIZ, Soner et al. Influenza A virus infection impacts systemic microbiota dynamics and causes quantitative enteric dysbiosis. In: Microbiome, 2018, vol. 6, n° 1, p. 9. doi: 10.1186/s40168-017-0386-z
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal2049-2618
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116downloads

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Update time03/15/2023 10:46:51 PM
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