en
Scientific article
English

Synergies of VEGF inhibition and photodynamic therapy in the treatment of age-related macular degeneration

Published inInvestigative ophthalmology & visual science, vol. 48, no. 4, p. 1767-1772
Publication date2007
Abstract

Photodynamic therapy (PDT) and the administration of compounds acting against vascular endothelial growth factor (anti-VEGF) are approved for the treatment of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). Experimental evidence that the combined use of both treatment options may improve therapeutic outcome is presented.

Keywords
  • Animals
  • Chick Embryo
  • Chorioallantoic Membrane/blood supply/drug effects
  • Disease Models, Animal
  • Drug Synergism
  • Fluorescein Angiography
  • Humans
  • Liposomes
  • Macular Degeneration/drug therapy
  • Microscopy, Fluorescence
  • Nanoparticles
  • Neovascularization, Physiologic/drug effects
  • Photochemotherapy
  • Photosensitizing Agents/therapeutic use
  • Porphyrins/therapeutic use
  • Recombinant Proteins/therapeutic use
  • Vascular Endothelial Growth Factor A/antagonists & inhibitors
  • Vascular Endothelial Growth Factor Receptor-1/therapeutic use
Citation (ISO format)
ZULUAGA, Maria-Fernanda et al. Synergies of VEGF inhibition and photodynamic therapy in the treatment of age-related macular degeneration. In: Investigative ophthalmology & visual science, 2007, vol. 48, n° 4, p. 1767–1772. doi: 10.1167/iovs.06-1224
Main files (1)
Article (Published version)
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Identifiers
ISSN of the journal0146-0404
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