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Synergies of VEGF inhibition and photodynamic therapy in the treatment of age-related macular degeneration

Zuluaga, Maria-Fernanda
Mailhos, Carolina
Robinson, Gregory
Shima, David T.
Published in Investigative Ophthalmology & Visual Science. 2007, vol. 48, no. 4, p. 1767-72
Abstract Photodynamic therapy (PDT) and the administration of compounds acting against vascular endothelial growth factor (anti-VEGF) are approved for the treatment of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). Experimental evidence that the combined use of both treatment options may improve therapeutic outcome is presented.
Keywords AnimalsChick EmbryoChorioallantoic Membrane/blood supply/drug effectsDisease Models, AnimalDrug SynergismFluorescein AngiographyHumansLiposomesMacular Degeneration/drug therapyMicroscopy, FluorescenceNanoparticlesNeovascularization, Physiologic/drug effectsPhotochemotherapyPhotosensitizing Agents/therapeutic usePorphyrins/therapeutic useRecombinant Proteins/therapeutic useVascular Endothelial Growth Factor A/antagonists & inhibitorsVascular Endothelial Growth Factor Receptor-1/therapeutic use
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PMID: 17389510

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Deposited on : 2011-02-01

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