Scientific article
Open access

Clinical outcomes and cataract formation rates in eyes 10 years after posterior phakic lens implantation for myopia

Published inJAMA Ophthalmology, vol. 134, no. 5, p. 487-494
Publication date2016

OBJECTIVE To report the rates of cataract development and refractive outcomes 10 years after ICL implantation. DESIGN, SETTING, AND PARTICIPANTS The study included 133 eyes of 78 patients undergoing consecutive V4 model ICL implantations, which took place from January 1, 1998, through December 31, 2004, at Jules-Gonin Eye Hospital, Lausanne, Switzerland. Data analysis was performed from January 1, 2014, to May 31, 2014. The lenses implanted were as follows: 53 V4 model ICLs of -15.5 D or greater, 73 V4 model ICLs of less than -15.5 diopter (D), and 7 V4 model toric ICLs for myopia. MAIN OUTCOMES AND MEASURES Rate of cataract surgery, lens opacity, ocular hypertension, refractive safety, predictability, and stability. RESULTS A total of 133 eyes of 78 patients (34 men and 44 women, with a mean [SD] age of 38.8 [9.2] years at enrollment) met the inclusion criteria. The rate of lens opacity development was 40.9%(95% CI, 32.7%-48.8%) and 54.8% (95% CI, 44.7%-63.0%) at 5 and 10 years, respectively. Phacoemulsification was performed in 5 eyes (4.9%; 95% CI, 1.0%-8.7%) and 18 eyes (18.3%; 95% CI, 10.1%-25.8%) at 5 and 10 years after ICL implantation, respectively. The vault height (distance between the posterior ICL surface and anterior lens surface) measured a mean (SD) of 426 (344) mu m immediately postoperatively, decreasing to 213 (169) mu m at 10 years. A smaller vault height was associated with the development of lens opacity and phacoemulsification (P = .005 and .008, respectively). The intraocular pressure was 15 mm Hg postoperatively, and there was no significant increase in intraocular pressure observed until the 10-year follow-up (16 mm Hg, P = .02). At 10 years, 12 eyes (12.9%; 95% CI, 5.6%-19.6%) had developed ocular hypertension that required topical medication. At 10 years, the mean (SD) safety index was 1.25 (0.57), with a manifest spherical equivalent of -0.5 D at 1-year postoperatively vs -0.7 D at 10 years postoperatively in eyes aimed at emmetropia. CONCLUSIONS AND RELEVANCE This retrospective single center study indicates that ICL implantation provides good long-term safety and stability of refraction in patients with high myopia compared with similar short-term studies. However, the rates of cataract formation and ocular hypertension at 10 years have important clinical implications, and as such this information should be part of the available patient information before ICL implantation.

  • ICL
Affiliation Not a UNIGE publication
Citation (ISO format)
GUBER, Ivo et al. Clinical outcomes and cataract formation rates in eyes 10 years after posterior phakic lens implantation for myopia. In: JAMA Ophthalmology, 2016, vol. 134, n° 5, p. 487–494. doi: 10.1001/jamaophthalmol.2016.0078
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Article (Published version)
ISSN of the journal2168-6165

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