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Doctoral thesis
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Brain Functional Connectivity and Network alterations in patients with focal epilepsy

Defense date2020-08-19
Abstract

Epilepsy is a chronic neurological disorder characterized by recurrent and unpredictable seizures. Electroencephalography (EEG) is fundamental in the diagnosis of patients. The extension and the properties of the epileptic network and of the entire pathological epileptic brain still remain under investigation. We investigated the connectivity changes during spike in patients that will or will not recover after surgery. We studied the brain networks properties, in patients with epilepsy compared to healthy controls. Finally, we used simultaneous intracranial-scalp-EEG to investigate the different network proprieties during perods with and without cortical spikes. We have consistently shown stronger ability of the network to propagate pathological activity in patients that won't recover after surgery and in patients as compared to controls. Also, in the same patient the ability of the network to integrate tha patological information is higher during cortical spike as compared to periods without epileptic activity.

eng
Keywords
  • Epilepsy
  • Connectivity
  • Source analysis
  • EEG
  • Network features
NoteDiplôme commun des univ. de Genève et Lausanne. Thèse en Neurosciences des universités de Genève et de Lausanne
Citation (ISO format)
CARBONI, Margherita. Brain Functional Connectivity and Network alterations in patients with focal epilepsy. 2020. doi: 10.13097/archive-ouverte/unige:142245
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Creation09/23/2020 1:58:00 PM
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