Article scientifique
Accès libre

Granulomas and nongranulomatous nodules after filler injection: Different complications require different treatments

Date de publication2020

Dermal fillers are widely used for facial rejuvenation and reconstruction and present fewer risks than surgical approaches. Nevertheless, several complications may occur, including nodule formation. A nodule is a clinical sign corresponding to different etiologies, such as overcorrection, infection, allergic reaction, or granuloma. However, their treatment represents a diagnostic challenge. We present a retrospective review of 26 consecutive patients who underwent a biopsy for facial nodule formation more than 3 months after filler injections, to determine the diagnosis of the nodule and type of filler used. All patients were women (mean age, 57.8 years). Some patients suffered from different localizations: lip, 14 cases; nasolabial folds, 6; cheeks, 5; infraorbital region, 5; the glabella, 2; the temporal region, 1; and chin, 1 case. Only 5 (19.2%) patients knew the type of filler used, and in another 4 cases, the injector was able to provide some information. In 65.4% of cases, the filler type was unknown. Histopathological analysis revealed a "granulomatous" nodule in 30 sites and a "non-granulomatous" nodule in 4 cases. Concerning the type of filler, 5 different histopathological patterns were found. Our results demonstrate that a clinical history and histopathological analysis whether to confirm or not to confirm the diagnosis of granuloma and to identify the type of filler are essential tools to achieve an accurate diagnosis of the problem-oriented treatment of nodules after dermal filler injections. We propose an algorithm for the management of nodules after filler injection.

  • Complication
  • Dermal fillers
  • Granuloma
  • Histopathology
  • Nodule.
Citation (format ISO)
MODARRESSI GHAVAMI, Seyed Ali, NIZET, Christophe, LOMBARDI, Tommaso. Granulomas and nongranulomatous nodules after filler injection: Different complications require different treatments. In: Journal of Plastic, Reconstructive & Aesthetic Surgery, 2020. doi: 10.1016/j.bjps.2020.08.012
Fichiers principaux (1)
Article (Accepted version)
ISSN du journal1748-6815

Informations techniques

Création22.09.2020 10:46:00
Première validation22.09.2020 10:46:00
Heure de mise à jour15.03.2023 22:36:28
Changement de statut15.03.2023 22:36:28
Dernière indexation30.08.2023 23:30:09
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