Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: systematic review and network meta-analysis

Wang, Ying; Ye, Zhikang; Ge, Long; Siemieniuk, Reed A C; Wang, Xin; Wang, Yingkai; Hou, Liangying; Ma, Zhuo; Agoritsas, Thomas; Vandvik, Per Olav; Perner, Anders; Møller, Morten H; Guyatt, Gordon H; Liu, Lihong

doi:10.1136/bmj.l6744

Scientific article

Meta-analysis

English

Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: systematic review and network meta-analysis

ContributorsWang, Ying; Ye, Zhikang; Ge, Long; Siemieniuk, Reed A C; Wang, Xin; Wang, Yingkai; Hou, Liangying; Ma, Zhuo; Agoritsas, Thomas

; Vandvik, Per Olav; Perner, Anders; Møller, Morten H; Guyatt, Gordon H; Liu, Lihong

Published inBMJ (Clinical Research Edition), vol. 368, l6744

Publication date2020

Abstract

To determine, in critically ill patients, the relative impact of proton pump inhibitors (PPIs), histamine-2 receptor antagonists (H2RAs), sucralfate, or no gastrointestinal bleeding prophylaxis (or stress ulcer prophylaxis) on outcomes important to patients.

Keywords

Critical Illness/therapy
Gastrointestinal Hemorrhage/etiology/prevention & control
Histamine H2 Antagonists/pharmacology
Humans
Patient Selection
Proton Pump Inhibitors/pharmacology
Risk Adjustment/methods

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Groupe Perrier Arnaud (Médecine interne générale, de réhabilitation et de gériatrie) (585)

Citation (ISO format)

WANG, Ying et al. Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: systematic review and network meta-analysis. In: BMJ (Clinical Research Edition), 2020, vol. 368, p. l6744. doi: 10.1136/bmj.l6744

Article (Published version)

CC BY-NC

Identifiers

PID : unige:141563
DOI : 10.1136/bmj.l6744
PMID : 31907166

Additional URL for this publicationhttps://www.bmj.com/content/368/bmj.l6744

Journal ISSN0959-8138

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Creation23/08/2020 18:10:00

First validation23/08/2020 18:10:00

Update15/03/2023 22:35:14

Status update15/03/2023 22:35:12

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Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: systematic review and network meta-analysis

To determine, in critically ill patients, the relative impact of proton pump inhibitors (PPIs), histamine-2 receptor antagonists (H2RAs), sucralfate, or no gastrointestinal bleeding prophylaxis (or stress ulcer prophylaxis) on outcomes important to patients.

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