Scientific article
Open access

Recent advances in intra-articular drug delivery systems for osteoarthritis therapy

Published inDrug Discovery Today, vol. 23, no. 10, p. 1761-1775
Publication date2018

Osteoarthritis (OA) is the most common degenerative disease of the joint. Despite many reports and numerous clinical trials, OA is not entirely understood, and there is no effective treatment available for this disease. To satisfy this unmet medical need, drug delivery systems (DDSs) containing disease-modifying OA drugs (DMOADs) for intra-articular (IA) administration are required to improve the health of OA patients. DDSs should provide controlled and/or sustained drug release, enabling long-term treatment with a reduced number of injections. This paper reviews the role and interaction among different tissues involved in OA and summarizes recent clinical trials and research on DDSs, focusing on small-molecule delivery. To achieve an ideal treatment, various key criteria have been identified to design and develop an IA DDS matching the clinical needs.

  • Animals
  • Antirheumatic Agents/administration & dosage
  • Delayed-Action Preparations
  • Drug Delivery Systems
  • Drug Design
  • Drug Development/methods
  • Humans
  • Injections, Intra-Articular
  • Osteoarthritis/drug therapy/physiopathology
Citation (ISO format)
MAUDENS, Pierre Marc Xavier, JORDAN, Olivier, ALLÉMANN, Eric. Recent advances in intra-articular drug delivery systems for osteoarthritis therapy. In: Drug Discovery Today, 2018, vol. 23, n° 10, p. 1761–1775. doi: 10.1016/j.drudis.2018.05.023
Main files (1)
Article (Accepted version)
ISSN of the journal1359-6446

Technical informations

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