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Scientific article
Open access
English

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

Published inPharmaceutics, vol. 12, 840
Publication date2020
Abstract

Bacterial infections occur when wound healing fails to reach the final stage of healing, which is usually hindered by the presence of different pathogens. Different topical antimicrobial agents are used to inhibit bacterial growth due to antibiotic failure in reaching the infected site, which is accompanied very often by increased drug resistance and other side effects. In this review, we focus on antimicrobial peptides (AMPs), especially those with a high potential of efficacy against multidrug-resistant and biofilm-forming bacteria and fungi present in wound infections. Currently, different AMPs undergo preclinical and clinical phase to combat infection-related diseases.AMP dendrimers (AMPDs) have been mentioned as potent microbial agents. Various AMP delivery strategies that are used to combat infection and modulate the healing rate—such as polymers,scaffolds, films and wound dressings, and organic and inorganic nanoparticles—have been discussed as well. New technologies such as Clustered Regularly Interspaced Short Palindromic Repeat(CRISPR)-associated protein (CRISPR-Cas) are taken into consideration as potential future tools for AMP delivery in skin therapy.

Keywords
  • Bacterial infection
  • Non-healing wounds
  • Antimicrobial resistance
  • Multidrug resistance
  • Antimicrobial peptides (AMPs)
  • AMP conjugates
  • AMP carriers and delivery systems
Citation (ISO format)
PATRULEA, Viorica, BORCHARD, Gerrit, JORDAN, Olivier. An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections. In: Pharmaceutics, 2020, vol. 12, p. 840. doi: 10.3390/pharmaceutics12090840
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Identifiers
ISSN of the journal1999-4923
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Technical informations

Creation09/04/2020 12:52:00 PM
First validation09/04/2020 12:52:00 PM
Update time03/15/2023 10:34:42 PM
Status update03/15/2023 10:34:41 PM
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