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Title

The glutamate receptor GluK2 contributes to the regulation of glucose homeostasis and its deterioration during aging

Authors
Abarkan, Myriam
Gaitan, Julien
Perrier, Romain
Jaffredo, Manon
Mulle, Christophe
Magnan, Christophe
Raoux, Matthieu
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Published in Molecular Metabolism. 2019, vol. 30, p. 152-160
Abstract Islets secrete neurotransmitters including glutamate which participate in fine regulation of islet function. The excitatory ionotropic glutamate receptor GluK2 of the kainate receptor family is widely expressed in brain and also found in islets, mainly in α and γ cells. α cells co-release glucagon and glutamate and the latter increases glucagon release via ionotropic glutamate receptors. However, neither the precise nature of the ionotropic glutamate receptor involved nor its role in glucose homeostasis is known. As isoform specific pharmacology is not available, we investigated this question in constitutive GluK2 knock-out mice (GluK2-/-) using adult and middle-aged animals to also gain insight in a potential role during aging.
Keywords AnimalsBlood Glucose/metabolismFemaleGlucagon/metabolismGlucagon-Secreting Cells/metabolismGlucose/metabolismHomeostasisInsulin/metabolismInsulin ResistanceInsulin SecretionInsulin-Secreting Cells/metabolismIslets of Langerhans/metabolismMaleMiceMice, Inbred C57BLMice, KnockoutReceptors, Glucagon/metabolismReceptors, Kainic Acid/metabolismAgingGRIK2GluK2IsletsKainate receptorMicroelectrode array
Identifiers
PMID: 31767166
Full text
Research group Création de tissus par bio-ingénieurie et régénération d'organes (1021)
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ABARKAN, Myriam et al. The glutamate receptor GluK2 contributes to the regulation of glucose homeostasis and its deterioration during aging. In: Molecular Metabolism, 2019, vol. 30, p. 152-160. doi: 10.1016/j.molmet.2019.09.011 https://archive-ouverte.unige.ch/unige:141442

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Deposited on : 2020-09-16

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