Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay

Shi, Liu; Westwood, Sarah; Baird, Alison L; Winchester, Laura; Dobricic, Valerija; Kilpert, Fabian; Hong, Shengjun; Franke, Andre; Hye, Abdul; Ashton, Nicholas J; Morgan, Angharad R; Bos, Isabelle; Vos, Stephanie J B; Buckley, Noel J; Kate, Mara Ten; Scheltens, Philip; Vandenberghe, Rik; Gabel, Silvy; Meersmans, Karen; Engelborghs, Sebastiaan; De Roeck, Ellen E; Sleegers, Kristel; Frisoni, Giovanni; Blin, Olivier; Richardson, Jill C; Bordet, Régis; Molinuevo, José L; Rami, Lorena; Wallin, Anders; Kettunen, Petronella; Tsolaki, Magda; Verhey, Frans; Lleó, Alberto; Alcolea, Daniel; Popp, Julius; Peyratout, Gwendoline; Martinez-Lage, Pablo; Tainta, Mikel; Johannsen, Peter; Teunissen, Charlotte E; Freund-Levi, Yvonne; Frölich, Lutz; Legido-Quigley, Cristina; Barkhof, Frederik; Blennow, Kaj; Zetterberg, Henrik; Baker, Susan; Morgan, B Paul; Streffer, Johannes; Visser, Pieter Jelle; Bertram, Lars; Lovestone, Simon; Nevado-Holgado, Alejo J

doi:10.1016/j.jalz.2019.06.4951

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Title		Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay
Authors		Shi, Liu Westwood, Sarah Baird, Alison L Winchester, Laura Dobricic, Valerija Kilpert, Fabian Hong, Shengjun Franke, Andre Hye, Abdul Ashton, Nicholas J Morgan, Angharad R Bos, Isabelle Vos, Stephanie J B Buckley, Noel J Kate, Mara Ten Scheltens, Philip Vandenberghe, Rik Gabel, Silvy Meersmans, Karen Engelborghs, Sebastiaan De Roeck, Ellen E Sleegers, Kristel Frisoni, Giovanni Blin, Olivier Richardson, Jill C Bordet, Régis Molinuevo, José L Rami, Lorena Wallin, Anders Kettunen, Petronella Tsolaki, Magda Verhey, Frans Lleó, Alberto Alcolea, Daniel Popp, Julius Peyratout, Gwendoline Martinez-Lage, Pablo Tainta, Mikel Johannsen, Peter Teunissen, Charlotte E Freund-Levi, Yvonne Frölich, Lutz Legido-Quigley, Cristina Barkhof, Frederik Blennow, Kaj Zetterberg, Henrik Baker, Susan Morgan, B Paul Streffer, Johannes Visser, Pieter Jelle Bertram, Lars Lovestone, Simon Nevado-Holgado, Alejo J show all authors [1 - 53]
Published in		Alzheimer's & Dementia. 2019, vol. 15, no. 11, p. 1478-1488
Abstract		Plasma proteins have been widely studied as candidate biomarkers to predict brain amyloid deposition to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. Most such biomarker studies are targeted to specific proteins or are biased toward high abundant proteins.
Keywords		Amyloid β — Causal relationship — Plasma proteomics — Replication — SOMAscan assay — Tau.
Identifiers		DOI: 10.1016/j.jalz.2019.06.4951 PMID: 31495601
Full text		Article (Published version) (870 Kb) - Free access Other version: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880298/
Structures		Faculté de médecine / Section de médecine clinique / Département de psychiatrie
Research group		Troubles de mémoire et maladie d'Alzeimer (935)
Project		European Commission: EMIF
Citation (ISO format)		SHI, Liu et al. Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay. In: Alzheimer's & Dementia, 2019, vol. 15, n° 11, p. 1478-1488. doi: 10.1016/j.jalz.2019.06.4951 https://archive-ouverte.unige.ch/unige:140834