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Scientific article
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English

Age-dependent dose calculations for common PET radionuclides and brain radiotracers in nonhuman primate computational models

Published inMedical Physics, vol. 47, no. 9, p. 4465-4476
Publication date2020
Abstract

The combination of nonhuman primates (NHPs) with the state-of-the-art molecular imaging technologies allows for within-subject longitudinal research aiming at gaining new insights into human normal and disease conditions and provides an ideal foundation for future translational studies of new diagnostic tools, medical interventions, and therapies. However, radiation dose estimations for nonhuman primates from molecular imaging probes are lacking and are difficult to perform experimentally. The aim of this work is to construct age-dependent NHP computational model series to estimate the absorbed dose to NHP specimens in common molecular imaging procedures.

Keywords
  • Monte Carlo simulations
  • Computational models
  • Molecular imaging
  • Nonhuman primates
  • Radiation dosimetry
NoteMerci de mettre à jour le pdfhttps://www.hug.ch/sites/interhug/files/structures/pinlab/documents/medphys2020_primate2.pdf
Funding
  • Swiss National Science Foundation - SNFN 320030-176052
Citation (ISO format)
XIE, Tianwu, CHEN, Xin, ZAIDI, Habib. Age-dependent dose calculations for common PET radionuclides and brain radiotracers in nonhuman primate computational models. In: Medical Physics, 2020, vol. 47, n° 9, p. 4465–4476. doi: 10.1002/mp.14333
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Article (Published version)
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Identifiers
ISSN of the journal0094-2405
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Technical informations

Creation07/14/2020 10:22:00 AM
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