en
Scientific article
Editorial
Open access
English

Predictive factors of treatment persistence in rheumatoid arthritis

Published inJoint, Bone, Spine
Publication date2020
Abstract

1. Introduction. Randomised controlled trials (RCTs) are considered the “gold standard” to establish drug efficacy, but they have typically a short follow-up and include only a limited number of patients, which rarely allows to assess safety appropriately. In addition, RCTs generally include highly selected patients and use strict protocols, which may not be representative of the challenges patients and health professionals face in real-life. By contrast, non-randomised studies, such as observational studies or epidemiological studies, have typically large numbers of patients, long follow-ups and highly heterogeneous study populations, which may allow to study subgroup of patients with different characteristics or establish generalisability in a less homogenous population. Therefore, real-world studies are increasingly recognised as an important mean to evaluate drug safety and effectiveness, and pharmaceutical companies are now more than ever required to demonstrate a real-life perspective in the regulatory process [...].

Keywords
  • Rheumatoid arthritis
  • Observational research
  • Epidemiology
  • Persistence
  • Retention
  • Drug
Citation (ISO format)
LAUPER, Kim, FINCKH, Axel. Predictive factors of treatment persistence in rheumatoid arthritis. In: Joint, Bone, Spine, 2020. doi: 10.1016/j.jbspin.2020.03.006
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1297-319X
345views
395downloads

Technical informations

Creation07/20/2020 2:30:00 PM
First validation07/20/2020 2:30:00 PM
Update time03/15/2023 10:28:29 PM
Status update03/15/2023 10:28:28 PM
Last indexation01/17/2024 10:41:56 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack