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Scientific article
English

Interaction between epithelial sodium channel γ-subunit and claudin-8 modulates paracellular sodium permeability in renal collecting duct

Published inJournal of the American Society of Nephrology, vol. 31, no. 5, p. 1009-1023
Publication date2020
Abstract

Water and solute transport across epithelia can occur via the transcellular or paracellular pathways. Tight junctions play a key role in mediating paracellular ion reabsorption in the kidney. In the renal collecting duct, which is a typical absorptive tight epithelium, coordination between transcellular sodium reabsorption and paracellular permeability may prevent the backflow of reabsorbed sodium to the tubular lumen along a steep electrochemical gradient.

Citation (ISO format)
SASSI, Ali et al. Interaction between epithelial sodium channel γ-subunit and claudin-8 modulates paracellular sodium permeability in renal collecting duct. In: Journal of the American Society of Nephrology, 2020, vol. 31, n° 5, p. 1009–1023. doi: 10.1681/ASN.2019080790
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ISSN of the journal1046-6673
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Creation08/24/2020 9:04:00 AM
First validation08/24/2020 9:04:00 AM
Update time03/15/2023 10:27:45 PM
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