Scientific article
Open access

Modified cyclodextrins as broad-spectrum antivirals

Published inScience Advances, vol. 6, no. 5, eaax9318
Publication date2020

Viral infections kill millions of people and new antivirals are needed. Nontoxic drugs that irreversibly inhibit viruses (virucidal) are postulated to be ideal. Unfortunately, all virucidal molecules described to date are cytotoxic. We recently developed nontoxic, broad-spectrum virucidal gold nanoparticles. Here, we develop further the concept and describe cyclodextrins, modified with mercaptoundecane sulfonic acids, to mimic heparan sulfates and to provide the key nontoxic virucidal action. We show that the resulting macromolecules are broad-spectrum, biocompatible, and virucidal at micromolar concentrations in vitro against many viruses [including herpes simplex virus (HSV), respiratory syncytial virus (RSV), dengue virus, and Zika virus]. They are effective ex vivo against both laboratory and clinical strains of RSV and HSV-2 in respiratory and vaginal tissue culture models, respectively. Additionally, they are effective when administrated in mice before intravaginal HSV-2 inoculation. Lastly, they pass a mutation resistance test that the currently available anti-HSV drug (acyclovir) fails.

Citation (ISO format)
JONES, Samuel T et al. Modified cyclodextrins as broad-spectrum antivirals. In: Science Advances, 2020, vol. 6, n° 5, p. eaax9318. doi: 10.1126/sciadv.aax9318
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ISSN of the journal2375-2548

Technical informations

Creation08/03/2020 4:26:00 PM
First validation08/03/2020 4:26:00 PM
Update time03/15/2023 10:26:00 PM
Status update03/15/2023 10:25:59 PM
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