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Scientific article
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English

Brain networks involved in Generalized Periodic Discharges (GPD) in post-anoxic-ischemic encephalopathy

Published inResuscitation
Publication date2020
Abstract

Aim: Generalized periodic discharge (GPD) is an EEG pattern of poor neurological outcome, frequently observed in comatose patients after cardiac arrest. The aim of our study was to identify the neuronal network generating ≤2.5 Hz GPD using EEG source localization and connectivity analysis. Methods: We analyzed 40 comatose adult patients with anoxic-ischemic encephalopathy, who had 19 channel-EEG recording. We computed electric source analysis based on distributed inverse solution (LAURA) and we estimated cortical activity in 82 atlas-based cortical brain regions. We applied directed connectivity analysis (Partial Directed Coherence) on these sources to estimate the main drivers. Results: Source analysis suggested that the GPD are generated in the cortex of limbic system in the majority of patients (87.5%). Connectivity analysis revealed main drivers located in thalamus and hippocampus for the large majority (80%) of patients, together with important activation also in amygdala (70%).

Keywords
  • GPD
  • Generalized Periodic Discharges
  • Anoxic-ischemic encephalopathy
  • Cardiac arrest
  • Non-convulsive status epilepticus
Funding
  • Swiss National Science Foundation - 163398; CRS115_170873; 169198
  • Swiss National Science Foundation - Sinergia 180365
Citation (ISO format)
DE STEFANO, Pia et al. Brain networks involved in Generalized Periodic Discharges (GPD) in post-anoxic-ischemic encephalopathy. In: Resuscitation, 2020. doi: 10.1016/j.resuscitation.2020.07.030
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Article (Accepted version)
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Identifiers
ISSN of the journal0300-9572
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133downloads

Technical informations

Creation08/13/2020 2:12:00 PM
First validation08/13/2020 2:12:00 PM
Update time03/15/2023 10:25:47 PM
Status update03/15/2023 10:25:46 PM
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