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Ménage à trois: virus, host, and microbiota in experimental infection models

Published in Trends in Microbiology. 2019, vol. 27, no. 5, p. 440-452
Abstract Infections of mammals with pathogenic viruses occur mostly in the polymicrobial environment of mucosal surfaces or the skin. In recent years our understanding of immune modulation by the commensal microbiota has increased dramatically. The microbiota is today accepted as the prime educator and maintainer of innate and adaptive immune functions. It became further apparent that some viral pathogens profit from the presence of commensal bacteria and their metabolites, especially in the intestinal tract. We further learned that the composition and abundance of the microbiota can change as a consequence of acute and chronic viral infections. Here we discuss recent developments in our understanding of the triangular relationship of virus, host, and microbiota under experimental infection settings.
Keywords AnimalsBacteria/metabolismDNA Viruses/immunology/pathogenicityDisease ModelsAnimalGastrointestinal MicrobiomeHumansImmunityInnateIntestinesMicrobiotaMucous Membrane/immunologySymbiosisVirus Diseases/immunology
PMID: 30638775
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Research group Modulation de la flore microbienne dans des hôtes infectés par un virus (947)
FNS: 310030_155949
(ISO format)
MAZEL-SANCHEZ, Beryl, YILDIZ, Soner, SCHMOLKE, Mirco. Ménage à trois: virus, host, and microbiota in experimental infection models. In: Trends in Microbiology, 2019, vol. 27, n° 5, p. 440-452. doi: 10.1016/j.tim.2018.12.004 https://archive-ouverte.unige.ch/unige:139627

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Deposited on : 2020-08-13

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