Scientific article
Open access

Ménage à trois: virus, host, and microbiota in experimental infection models

Published inTrends in Microbiology, vol. 27, no. 5, p. 440-452
Publication date2019

Infections of mammals with pathogenic viruses occur mostly in the polymicrobial environment of mucosal surfaces or the skin. In recent years our understanding of immune modulation by the commensal microbiota has increased dramatically. The microbiota is today accepted as the prime educator and maintainer of innate and adaptive immune functions. It became further apparent that some viral pathogens profit from the presence of commensal bacteria and their metabolites, especially in the intestinal tract. We further learned that the composition and abundance of the microbiota can change as a consequence of acute and chronic viral infections. Here we discuss recent developments in our understanding of the triangular relationship of virus, host, and microbiota under experimental infection settings.

  • Animals
  • Bacteria/metabolism
  • DNA Viruses/immunology/pathogenicity
  • Disease Models
  • Animal
  • Gastrointestinal Microbiome
  • Humans
  • Immunity
  • Innate
  • Intestines
  • Microbiota
  • Mucous Membrane/immunology
  • Symbiosis
  • Virus Diseases/immunology
Citation (ISO format)
MAZEL-SANCHEZ, Beryl, YILDIZ, Soner, SCHMOLKE, Mirco. Ménage à trois: virus, host, and microbiota in experimental infection models. In: Trends in Microbiology, 2019, vol. 27, n° 5, p. 440–452. doi: 10.1016/j.tim.2018.12.004
Main files (1)
Article (Accepted version)
ISSN of the journal0966-842X

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