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Scientific article
English

T cells, B cells, and polarized immune response in the pathogenesis of fibrosis and systemic sclerosis

Contributors

Chizzolini, Carlo

Published in

Current opinion in rheumatology, vol. 20, no. 6, p. 707-712

Publication date

2008

Abstract

PURPOSE OF REVIEW: A better comprehension of the interactions between cells of the adaptive immune system with fibroblasts and endothelial cells is required to understand abnormal extracellular matrix deposition, development of pathologic fibrosis, and vasculopathy. RECENT FINDINGS: Skin T cells with high IL-4 production potential and peripheral blood T cells preferentially expressing chemokine receptors associated with Th2 functions are found in individuals with active systemic sclerosis. Animal models indicate that Th2 cells and IL-13 can induce muscular hypertrophy in pulmonary arterial vasculature. In bleomycin-induced fibrosis, B cells produce fibrogenic cytokines upon interaction of an endogenous ligand (hyaluronan) with toll-like receptor-4. In the sclerodermatous graft versus host model, the lack of tumor necrosis factor-production by CD4+ T cells is permissive for fibrosis development. Dermal fibrosis and capillary loss typical of systemic sclerosis can be reversible after high-dose immunosuppression and hematopoietic stem cell transplantation. SUMMARY: Although immunosuppressive strategies to treat patients with systemic sclerosis and allied conditions are largely disappointing, thus indicating a permissive rather than causative role of immunoinflammatory events characteristic of the disease, new findings stress that cells of the adaptive immune system play important roles in assisting fibrogenesis and vascular abnormalities. This may help in identifying efficacious strategies aimed at their control.

Keywords

  • Animals
  • B-Lymphocytes/immunology
  • Cytokines/metabolism
  • Disease Models, Animal
  • Fibrosis
  • Humans
  • Models, Immunological
  • Scleroderma, Systemic/etiology/immunology/pathology
  • T-Lymphocytes/immunology

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

CHIZZOLINI, Carlo. T cells, B cells, and polarized immune response in the pathogenesis of fibrosis and systemic sclerosis. In: Current opinion in rheumatology, 2008, vol. 20, n° 6, p. 707–712. doi: 10.1097/BOR.0b013e32830c45ae

Main files (1)

Article (Accepted version)

Identifiers

Additional URL for this publication

http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=fulltext&AN=00002281-200811000-00013&LSLINK=80&D=ovft

Journal ISSN

1040-8711
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Technical informations

Creation

07/04/2009 09:53:00

First validation

07/04/2009 09:53:00

Update

14/03/2023 15:04:21

Status update

14/03/2023 15:04:21

Last indexation

29/10/2024 11:27:51
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