UNIGE document Scientific Article
previous document  unige:1394  next document
add to browser collection

T cells, B cells, and polarized immune response in the pathogenesis of fibrosis and systemic sclerosis

Published in Current Opinion in Rheumatology. 2008, vol. 20, no. 6, p. 707-712
Abstract PURPOSE OF REVIEW: A better comprehension of the interactions between cells of the adaptive immune system with fibroblasts and endothelial cells is required to understand abnormal extracellular matrix deposition, development of pathologic fibrosis, and vasculopathy. RECENT FINDINGS: Skin T cells with high IL-4 production potential and peripheral blood T cells preferentially expressing chemokine receptors associated with Th2 functions are found in individuals with active systemic sclerosis. Animal models indicate that Th2 cells and IL-13 can induce muscular hypertrophy in pulmonary arterial vasculature. In bleomycin-induced fibrosis, B cells produce fibrogenic cytokines upon interaction of an endogenous ligand (hyaluronan) with toll-like receptor-4. In the sclerodermatous graft versus host model, the lack of tumor necrosis factor-production by CD4+ T cells is permissive for fibrosis development. Dermal fibrosis and capillary loss typical of systemic sclerosis can be reversible after high-dose immunosuppression and hematopoietic stem cell transplantation. SUMMARY: Although immunosuppressive strategies to treat patients with systemic sclerosis and allied conditions are largely disappointing, thus indicating a permissive rather than causative role of immunoinflammatory events characteristic of the disease, new findings stress that cells of the adaptive immune system play important roles in assisting fibrogenesis and vascular abnormalities. This may help in identifying efficacious strategies aimed at their control.
Keywords AnimalsB-Lymphocytes/immunologyCytokines/metabolismDisease Models, AnimalFibrosisHumansModels, ImmunologicalScleroderma, Systemic/etiology/immunology/pathologyT-Lymphocytes/immunology
PMID: 18946333
Full text
Research group La matrice extracellulaire (651)
(ISO format)
CHIZZOLINI, Carlo. T cells, B cells, and polarized immune response in the pathogenesis of fibrosis and systemic sclerosis. In: Current Opinion in Rheumatology, 2008, vol. 20, n° 6, p. 707-712. https://archive-ouverte.unige.ch/unige:1394

228 hits

0 download


Deposited on : 2009-04-27

Export document
Format :
Citation style :