Scientific article
Open access

Low Dose Radiation Therapy and Convalescent Plasma: How a Hybrid Method May Maximize Benefits for COVID-19 Patients

Published inJournal of Biomedical Physics and Engineering, vol. 10, no. 4, p. 387-394
Publication date2020

Physicians and scientists around the world are aggressively attempting to develop effective treatment strategies. The treatment goal is to reduce the fatality rate in 15% to 20% of individuals infected with SARS-CoV-2 who develop severe inflammatory conditions that can lead to pneumonia, and acute respiratory distress syndrome. These conditions are major causes of death in these patients. Convalescent plasma (CP) collected from patients recovered from the novel corona virus disease (COVID-19) has been considered as an effective treatment method for COVID-19. Moreover, low-dose radiation therapy (LDRT) for COVID-19 pneumonia was historically used to treat pneumonia during the first half of the 20th century. The concept of LDRT for COVID-19 pneumonia was first introduced in March 2020. Later scientists from Canada, Spain, United States, Germany and France also confirmed the potential efficacy of LDRT for treatment of COVID-19 pneumonia. The rationale behind introducing LDRT as an effective treatment method for pneumonia in COVID-19 patients is not only due to its anti-inflammatory effect, but also in optimization of the activity of the immune system. Moreover, LDRT, unlike other treatment methods such as antiviral drugs, does not have the key disadvantage of exerting a significant selective pressure on the SARS-CoV-2 virus and hence does not lead to evolution of the virus through mutations. Given these considerations, we believe that a hybrid treatment including both CP and LDRT can trigger synergistic responses that will help healthcare providers in mitigating today's COVID-19 pandemic.

  • Low Dose Radiation
  • Radiotherapy
  • COVID-19
  • Convalescent Plasma
  • Anti-Inflammatory Responses
  • Immune System
  • Selective Pressure
  • Mutations
Citation (ISO format)
ABDOLLAHI, H. et al. Low Dose Radiation Therapy and Convalescent Plasma: How a Hybrid Method May Maximize Benefits for COVID-19 Patients. In: Journal of Biomedical Physics and Engineering, 2020, vol. 10, n° 4, p. 387–394. doi: 10.31661/jbpe.v0i0.2006-1125
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Article (Published version)
ISSN of the journal2251-7200

Technical informations

Creation07/27/2020 10:45:00 AM
First validation07/27/2020 10:45:00 AM
Update time03/15/2023 10:23:23 PM
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