Abnormal development and dysconnectivity of distinct thalamic nuclei in patients with 22q11.2 deletion syndrome experiencing auditory hallucinations

Mancini, Valentina; Zoeller, Daniela; Schneider, Maude; Schaer, Marie; Eliez, Stéphan

doi:10.1016/j.bpsc.2020.04.015

Scientific article

Open access

English

Abnormal development and dysconnectivity of distinct thalamic nuclei in patients with 22q11.2 deletion syndrome experiencing auditory hallucinations

ContributorsMancini, Valentina

; Zoeller, Daniela; Schneider, Maude; Schaer, Marie; Eliez, Stéphan

Published inBiological Psychiatry

Publication date2020

Abstract

Several studies in patients with schizophrenia have demonstrated an abnormal thalamic volume and thalamocortical connectivity. Specifically, hyperconnectivity with somatosensory areas has been related to the presence of auditory hallucinations (AHs). The 22q11.2 deletion syndrome is a neurogenetic disorder conferring proneness to develop schizophrenia, and deletion carriers (22qdel carriers) experience hallucinations to a greater extent than the general population.

Keywords

Auditory cortex
Medial geniculate nucleus
Nucleus reuniens
Psychosis
Thalamocortical comaturation
Wernicke's area

Affiliation

Research group

Funding

Swiss National Science Foundation - 324730_121996, 324730_144260, 51NF40-158776, PZ00P1_174206, 163859

Citation (ISO format)

MANCINI, Valentina et al. Abnormal development and dysconnectivity of distinct thalamic nuclei in patients with 22q11.2 deletion syndrome experiencing auditory hallucinations. In: Biological Psychiatry, 2020. doi: 10.1016/j.bpsc.2020.04.015

Article (Published version)

CC BY

Identifiers

PID : unige:139054
DOI : 10.1016/j.bpsc.2020.04.015
PMID : 32620531

Commercial URLhttps://www.sciencedirect.com/science/article/pii/S2451902220301099

ISSN of the journal0006-3223

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Creation07/13/2020 4:02:00 PM

First validation07/13/2020 4:02:00 PM

Update time03/15/2023 10:23:12 PM

Status update03/15/2023 10:23:11 PM

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Abnormal development and dysconnectivity of distinct thalamic nuclei in patients with 22q11.2 deletion syndrome experiencing auditory hallucinations

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