

![]() |
Humoral and cellular rejection after combined liver-kidney transplantation in low immunologic risk recipients |
|
Authors | ![]() | |
Published in | Transplant international. 2009, vol. 22, no. 2, p. 242-246 | |
Abstract | Combined liver-kidney transplantation is considered a low risk for immunologic complication. We report an unusual case of identical ABO liver-kidney recipient without preformed anti-human leukocyte antigen (HLA) antibodies, transplanted across a T- and B-cell-negative cross-match and complicated by early acute humoral and cellular rejection, first in the liver then in the kidney. While analyzing the immunologic complications in our cohort of 12 low-risk combined liver-kidney recipients, only one recipient experienced a rejection episode without detection of anti-HLA antibody over time. Although humoral or cellular rejection is rare after combined kidney-liver transplantation, our data suggest that even in low-risk recipients, the liver does not always systematically protect the kidney from acute rejection. Indeed, the detection of C4d in the liver should be carefully followed after combined liver-kidney transplantation. | |
Keywords | ABO Blood-Group System/immunology — Adult — Complement C4b/immunology — Female — Graft Rejection/drug therapy/immunology — Histocompatibility Testing — Humans — Immunosuppressive Agents/therapeutic use — Kidney Transplantation/adverse effects/immunology — Liver Transplantation/adverse effects/immunology — Male — Peptide Fragments/immunology — Treatment Outcome | |
Identifiers | PMID: 18954373 | |
Full text | ||
Structures | ||
Research groups | Analyse protéomique et Analyse génomique des maladies rénales (659) Hépatologie chirurgicale (327) Métastases du foie (657) Transplantation Immunologie et Osteoimmunologie (561) | |
Citation (ISO format) | HADAYA, Karine et al. Humoral and cellular rejection after combined liver-kidney transplantation in low immunologic risk recipients. In: Transplant international, 2009, vol. 22, n° 2, p. 242-246. doi: 10.1111/j.1432-2277.2008.00775.x https://archive-ouverte.unige.ch/unige:1390 |