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Gray matter changes related to microglial activation in Alzheimer's disease

Malpetti, Maura
Mak, Elijah
Williams, Guy B.
Bevan-Jones, W. Richard
Carter, Stephen F.
Passamonti, Luca
Fryer, Tim D.
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Published in Neurobiology of Aging. 2020, vol. 94, p. 236-242
Abstract Neuroinflammation is increasingly recognized as playing a key pathogenetic role in Alzheimer's disease (AD). We examined the relationship between in vivo neuroinflammation and gray matter (GM) changes. Twenty-eight subjects with clinically probable AD (n = 14) and amyloid-positive mild cognitive impairment (n = 14) (age 71.9 ± 8.4 years, 46% female) and 24 healthy controls underwent structural 3T brain MRI. AD/mild cognitive impairment participants exhibited GM atrophy and cortical thinning in AD-related temporoparietal regions (false discovery rate–corrected p < 0.05). Patients also showed increased microglial activation in temporal cortices. Higher 11C-PK11195 binding in these regions was associated with reduced volume and cortical thickness in parietal, occipital, and cingulate areas (false discovery rate p < 0.05). Hippocampal GM atrophy and parahippocampal cortical thinning were related to worse cognition (p < 0.05), but these effects were not mediated by microglial activation. This study demonstrates an association between in vivo microglial activation and markers of GM damage in AD, positioning neuroinflammation as a potential target for immunotherapeutic strategies.
Keywords Alzheimer's diseaseNeuroinflammationPETGrey matterAtrophyCortical thicknessMRI
PMID: 32663716
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NICASTRO, Nicolas et al. Gray matter changes related to microglial activation in Alzheimer's disease. In: Neurobiology of Aging, 2020, vol. 94, p. 236-242. doi: 10.1016/j.neurobiolaging.2020.06.010 https://archive-ouverte.unige.ch/unige:138790

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Deposited on : 2020-07-31

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