RB137 and RB138 antibodies recognize human cathelicidin LL37 by ELISA

Palazzo, Raffaella; Pietraforte, Immacolata; Chizzolini, Carlo; Lande, Roberto; Frasca, Loredana

doi:10.24450/journals/abrep.2020.e188

Scientific article

English

RB137 and RB138 antibodies recognize human cathelicidin LL37 by ELISA

ContributorsPalazzo, Raffaella; Pietraforte, Immacolata; Chizzolini, Carlo; Lande, Roberto; Frasca, Loredana

Published inAntibody Reports, vol. 3, no. 3, e188

Collection

OAP Journals - Antibody Reports

Publication date2020

Abstract

LL37 is a cationic antimicrobial peptide (AMP), which can undergo post-translational modifications (PTM), such as citrullination and carbamylation. We demonstrate here that recombinant antibodies RB137 and RB138 are specific for native LL37 and do not recognize modified LL37 (citrullinated and carbamylated). They thus represent tools to assess the presence of native, unmodified LL37 in body fluids by ELISA.

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme

Research groups

Phagocytose (140)

Citation (ISO format)

PALAZZO, Raffaella et al. RB137 and RB138 antibodies recognize human cathelicidin LL37 by ELISA. In: Antibody Reports, 2020, vol. 3, n° 3, p. e188. doi: 10.24450/journals/abrep.2020.e188

Article (Published version)

CC BY

Identifiers

PID : unige:138774
DOI : 10.24450/journals/abrep.2020.e188

ISSN of the journal2624-8557

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Creation31/07/2020 17:28:59

First validation31/07/2020 17:28:59

Update time15/03/2023 22:21:24

Status update15/03/2023 22:21:23

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RB137 and RB138 antibodies recognize human cathelicidin LL37 by ELISA

Technical informations