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Title

GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults

Authors
Quevenco, F.C.
Schreiner, S.J.
van Bergen, J.M.G.
Kirchner, T.
Wyss, M.
Steininger, S.C.
Gietl, A.
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Published in NeuroImage. Clinical. 2019, vol. 22, 101776
Abstract Effects of beta-amyloid accumulation on neuronal function precede the clinical manifestation of Alzheimer's disease (AD) by years and affect distinct cognitive brain networks. As previous studies suggest a link between beta-amyloid and dysregulation of excitatory and inhibitory neurotransmitters, we aimed to investigate the impact of GABA and glutamate on beta-amyloid related functional connectivity.
Keywords 7-Tesla MRIAlzheimer's diseaseBeta-amyloidDynamic functional connectivityGABAGlutamateMagnetic resonance spectroscopic imagingPiB-PET
Identifiers
PMID: 30927605
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Research group Traitement d'images médicales (893)
Project
Swiss National Science Foundation: 33CM30-124111, 320030-125378
Citation
(ISO format)
QUEVENCO, F.C. et al. GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults. In: NeuroImage: Clinical, 2019, vol. 22, p. 101776. doi: 10.1016/j.nicl.2019.101776 https://archive-ouverte.unige.ch/unige:138716

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Deposited on : 2020-07-31

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