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GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults

ContributorsQuevenco, F.C.; Schreiner, S.J.; Preti, Maria Giulia; van Bergen, J.M.G.; Kirchner, T.; Wyss, M.; Steininger, S.C.; Gietl, A.; Leh, S.E.; Buck, A.; Pruessmann, K.P.; Hock, C.; Nitsch, R.M.; Henning, A.; Van De Ville, Dimitriorcid; Unschuld, Paul
Published inNeuroImage: Clinical, vol. 22, 101776
Publication date2019
Abstract

Effects of beta-amyloid accumulation on neuronal function precede the clinical manifestation of Alzheimer's disease (AD) by years and affect distinct cognitive brain networks. As previous studies suggest a link between beta-amyloid and dysregulation of excitatory and inhibitory neurotransmitters, we aimed to investigate the impact of GABA and glutamate on beta-amyloid related functional connectivity.

Keywords
  • 7-Tesla MRI
  • Alzheimer's disease
  • Beta-amyloid
  • Dynamic functional connectivity
  • GABA
  • Glutamate
  • Magnetic resonance spectroscopic imaging
  • PiB-PET
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Funding
Citation (ISO format)
QUEVENCO, F.C. et al. GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults. In: NeuroImage: Clinical, 2019, vol. 22, p. 101776. doi: 10.1016/j.nicl.2019.101776
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Article (Published version)
accessLevelPublic CC BY-NC-ND
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Additional URL for this publicationhttps://linkinghub.elsevier.com/retrieve/pii/S2213158219301263
Journal ISSN2213-1582
409views
255downloads

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Update27/08/2025 08:38:12
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