GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults

Quevenco, F.C.; Schreiner, S.J.; Preti, Maria Giulia; van Bergen, J.M.G.; Kirchner, T.; Wyss, M.; Steininger, S.C.; Gietl, A.; Leh, S.E.; Buck, A.; Pruessmann, K.P.; Hock, C.; Nitsch, R.M.; Henning, A.; Van De Ville, Dimitri; Unschuld, Paul

doi:10.1016/j.nicl.2019.101776

Scientific article

Open access

English

GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults

ContributorsQuevenco, F.C.; Schreiner, S.J.; Preti, Maria Giulia; van Bergen, J.M.G.; Kirchner, T.; Wyss, M.; Steininger, S.C.; Gietl, A.; Leh, S.E.; Buck, A.; Pruessmann, K.P.; Hock, C.; Nitsch, R.M.; Henning, A.; Van De Ville, Dimitri

; Unschuld, Paul

Published inNeuroImage: Clinical, vol. 22, 101776

Publication date2019

Abstract

Effects of beta-amyloid accumulation on neuronal function precede the clinical manifestation of Alzheimer's disease (AD) by years and affect distinct cognitive brain networks. As previous studies suggest a link between beta-amyloid and dysregulation of excitatory and inhibitory neurotransmitters, we aimed to investigate the impact of GABA and glutamate on beta-amyloid related functional connectivity.

Keywords

7-Tesla MRI
Alzheimer's disease
Beta-amyloid
Dynamic functional connectivity
GABA
Glutamate
Magnetic resonance spectroscopic imaging
PiB-PET

Affiliation

Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

Research group

Traitement d'images médicales (893)

Funding

Swiss National Science Foundation - 33CM30-124111, 320030-125378

Citation (ISO format)

QUEVENCO, F.C. et al. GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults. In: NeuroImage: Clinical, 2019, vol. 22, p. 101776. doi: 10.1016/j.nicl.2019.101776

Article (Published version)

CC BY-NC-ND

Identifiers

PID : unige:138716
DOI : 10.1016/j.nicl.2019.101776
PMID : 30927605

Commercial URLhttps://linkinghub.elsevier.com/retrieve/pii/S2213158219301263

ISSN of the journal2213-1582

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GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults

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