IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome

Yasin, Shima; Fall, Ndate; Brown, Rachel A; Henderlight, Maggie; Canna, Scott W; Girard, Charlotte; Gabay, Cem; Grom, Alexei A; Schulert, Grant S

doi:10.1093/rheumatology/kez282

Scientific article

English

IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome

ContributorsYasin, Shima; Fall, Ndate; Brown, Rachel A; Henderlight, Maggie; Canna, Scott W; Girard, Charlotte; Gabay, Cem; Grom, Alexei A; Schulert, Grant S

Published inRheumatology, vol. 59, no. 2, p. 361-366

Publication date2020

Abstract

Systemic juvenile idiopathic arthritis (sJIA) is a childhood arthritis with features of autoinflammation and high risk of macrophage activation syndrome (MAS). IL-18 has been shown to have key roles in sJIA and MAS. We aimed to examine IL-18 levels in sJIA in relation to disease activity and history of MAS and other disease biomarkers namely S100 proteins and CXCL9.

Keywords

Arthritis, Juvenile/blood/diagnosis
Biomarkers/blood
Chemokine CXCL9/blood
Female
Ferritins/blood
Humans
Interleukin-18/blood
Macrophage Activation Syndrome/blood/diagnosis
Male
S100 Proteins/blood
Severity of Illness Index

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Mécanisme de l'inflammation articulaire (44)

Citation (ISO format)

YASIN, Shima et al. IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome. In: Rheumatology, 2020, vol. 59, n° 2, p. 361–366. doi: 10.1093/rheumatology/kez282

Article (Published version)

Identifiers

PID : unige:138640
DOI : 10.1093/rheumatology/kez282
PMID : 31326996

Commercial URLhttps://academic.oup.com/rheumatology/article/59/2/361/5536572

ISSN of the journal1462-0324

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Creation20/07/2020 14:29:00

First validation20/07/2020 14:29:00

Update time15/03/2023 22:20:41

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IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome

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