Genes controlling pancreas ontogeny

Bonal, Claire Brune; Herrera, Pedro Luis

doi:10.1387/ijdb.072444cb

Scientific article

English

Genes controlling pancreas ontogeny

Contributors

Bonal, Claire Brune; Herrera, Pedro Luis

Published in

The International journal of developmental biology, vol. 52, no. 7, p. 823-835

Publication date

2008

Abstract

The pancreas develops from two separate and independent endodermal primordia. The molecular events supporting the early morphological changes that give rise to the formation of the dorsal and ventral pancreatic buds result from coordinated responses to extrinsic and intrinsic signals. The extrinsic signals are involved in processes dictating whether progenitor cells remain as immature or as committed precursors. After specification, the sequential activation of transcription factors determines cell autonomously the commitment and differentiation of these progenitors. During pancreas development, the roles of extrinsic and intrinsic signals are variable, depending on the particular competence of each progenitor cell. We summarize in this review the main events, at the level of gene expression, which are involved in the early stages of pancreas development.

Keywords

Animals
Cell Differentiation/genetics
Cell Lineage/genetics
Embryo, Mammalian
Endoderm/cytology/metabolism
Gene Expression Regulation, Developmental
Homeodomain Proteins/genetics/metabolism
Islets of Langerhans/metabolism
Mesoderm/cytology/metabolism
Organogenesis/genetics
Pancreas/cytology/metabolism
Signal Transduction/genetics
Stem Cells/cytology/metabolism/physiology
Trans-Activators/genetics/metabolism
Transcription Factors/genetics/metabolism

UNIGE affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement

UNIGE research groups

Types cellulaires pancréatiques pendant l'ontogénèse (522)

Citation (ISO format)

BONAL, Claire Brune, HERRERA, Pedro Luis. Genes controlling pancreas ontogeny. In: The International journal of developmental biology, 2008, vol. 52, n° 7, p. 823–835. doi: 10.1387/ijdb.072444cb

Article (Accepted version)

Identifiers

PID : unige:1386
DOI : 10.1387/ijdb.072444cb
PMID : 18956314

Journal ISSN

0214-6282

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Creation

07/04/2009 10:44:00

First validation

07/04/2009 10:44:00

Update

14/03/2023 15:04:20

Status update

14/03/2023 15:04:19

Last indexation

29/10/2024 11:27:42

Genes controlling pancreas ontogeny

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

Main files (1)

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Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation