Next Generation Sequencing Analysis in Early Onset Dementia Patients

Bonvicini, Cristian; Scassellati, Catia; Benussi, Luisa; Di Maria, Emilio; Maj, Carlo; Ciani, Miriam; Fostinelli, Silvia; Mega, Anna; Bocchetta, Martina; Lanzi, Gaetana; Giacopuzzi, Edoardo; Ferraboli, Sergio; Pievani, Michela; Fedi, Virginia; Defanti, Carlo Alberto; Giliani, Silvia; Alzheimer's Disease Neuroimaging, Initiative; Frisoni, Giovanni; Ghidoni, Roberta; Gennarelli, Massimo

doi:10.3233/JAD-180482

Scientific article

English

Next Generation Sequencing Analysis in Early Onset Dementia Patients

Published inJournal of Alzheimer's Disease, vol. 67, no. 1, p. 243-256

Publication date2019

Abstract

Early onset dementias (EOD) are rare neurodegenerative dementias that present before 65 years. Genetic factors have a substantially higher pathogenetic contribution in EOD patients than in late onset dementia.

Keywords

Age of Onset
Aged
Alleles
Apolipoproteins E/genetics
C9orf72 Protein/genetics
Dementia/genetics
Female
Genetic Association Studies
Genetic Variation
High-Throughput Nucleotide Sequencing/trends
Humans
Male
Middle Aged
Presenilin-2/genetics
Prion Proteins/genetics
Retrospective Studies
Risk Assessment

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie

Research groups

Troubles de mémoire et maladie d'Alzeimer (935)

Citation (ISO format)

BONVICINI, Cristian et al. Next Generation Sequencing Analysis in Early Onset Dementia Patients. In: Journal of Alzheimer’s Disease, 2019, vol. 67, n° 1, p. 243–256. doi: 10.3233/JAD-180482

Article (Published version)

CC BY-NC

Identifiers

PID : unige:138509
DOI : 10.3233/JAD-180482
PMID : 30530974

Additional URL for this publicationhttps://content.iospress.com/articles/journal-of-alzheimers-disease/jad180482

Journal ISSN1387-2877

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Creation10/07/2020 12:00:00

First validation10/07/2020 12:00:00

Update15/03/2023 22:18:51

Status update15/03/2023 22:18:50

Last indexation31/10/2024 19:14:46

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Next Generation Sequencing Analysis in Early Onset Dementia Patients

Early onset dementias (EOD) are rare neurodegenerative dementias that present before 65 years. Genetic factors have a substantially higher pathogenetic contribution in EOD patients than in late onset dementia.

Technical informations